114480-27-2Relevant academic research and scientific papers
Aza-Matteson Reactions via Controlled Mono-and Double-Methylene Insertions into Nitrogen-Boron Bonds
Xie, Qiqiang,Dong, Guangbin
supporting information, p. 14422 - 14427 (2021/09/29)
Boron-homologation reactions represent an efficient and programmable approach to prepare alkylboronates, which are valuable and versatile synthetic intermediates. The typical boron-homologation reaction, also known as the Matteson reaction, involves formal carbenoid insertions into C-B bonds. Here we report the development of aza-Matteson reactions via carbenoid insertions into the N-B bonds of aminoboranes. By changing the leaving groups of the carbenoids and altering Lewis acid activators, selective mono- and double-methylene insertions can be realized to access various α- and β-boron-substituted tertiary amines, respectively, from common secondary amines. The derivatization of complex amine-containing bioactive molecules, diverse functionalization of the boronate products, and sequential insertions of different carbenoids have also been achieved.
SYNTHESE DES MORPHOLINES. II. ALLYLATION CHIMIOSELECTIVE DES 2-AMINOALCOOLS, PRODUITS DE DEPART POUR LA FORMATION DES MORPHOLINES.
Dobrev, Alexandre,Spasov, Stefan,Lattes, Armand
, p. 1601 - 1619 (2007/10/02)
La reaction d'allylation des 2-aminoalcools est une reaction chimioselective donnant un acces facile et avec des bons rendements aux alcools correspondants exclusivement N-allyles.Leurs structures ont ete prouvees par spectrometrie de masse, IR et 1H RMN.
Aminopiperidines, their production and the pharmaceutical compositions incorporating them
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, (2008/06/13)
This invention relates to 4-aminopiperidines and more precisely to 4-aminopiperidines the nitrogen atom of the piperidine ring is substituted with an aryl lower alkyl side-chain. This invention also relates to processes for producing the same. This invention further extends to pharmaceutical compositions and to the method of using the same.
