510732-17-9

Basic information

• Product Name: methanesulfonic acid 2-[2-(1-acetylamino-ethyl)-6-benzyloxy-3,5-dimethoxy-phenyl]-1-methyl-ethyl ester
• Synonyms: methanesulfonic acid 2-[2-(1-acetylamino-ethyl)-6-benzyloxy-3,5-dimethoxy-phenyl]-1-methyl-ethyl ester
• CAS NO: 510732-17-9
• Molecular Weight: 465.568
• Mol File: 510732-17-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: methanesulfonic acid 2-[2-(1-acetylamino-ethyl)-6-benzyloxy-3,5-dimethoxy-phenyl]-1-methyl-ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: methanesulfonic acid 2-[2-(1-acetylamino-ethyl)-6-benzyloxy-3,5-dimethoxy-phenyl]-1-methyl-ethyl ester(510732-17-9)
• EPA Substance Registry System: methanesulfonic acid 2-[2-(1-acetylamino-ethyl)-6-benzyloxy-3,5-dimethoxy-phenyl]-1-methyl-ethyl ester(510732-17-9)

Safety Data

• Hazardous Substances Data: 510732-17-9(Hazardous Substances Data)

Upstream product

• 510732-13-5 N-{1-[2-allyl-3-(benzyloxy)-4,6-dimethoxyphenyl]ethyl}phthalimide 
• 510732-14-6 N-{1-[2-allyl-3-(benzyloxy)-4,6-dimethoxyphenyl]ethyl}acetamide 
• 627519-32-8 1-[2-allyl-3-(benzyloxy)-4,6-dimethoxyphenyl]ethylamine 
• 225114-44-3 1-(2-Allyl-3-benzyloxy-4,6-dimethoxyphenyl)ethanol 
• 124-63-0 methanesulfonyl chloride 
• 510732-16-8 N-{1-[3-(benzyloxy)-2-(2-hydroxypropyl)-4,6-dimethoxyphenyl]ethyl}acetamide 

Relevant articles and documents

Synthesis of N-acetyl-1,3-dimethyltetrahydroisoquinolines by intramolecular amidomercuration: Stereochemical aspects

Mercury(II)-mediated ring closure of N-[1-(2-allyl-3-benzyloxy-4,6-dimethoxyphenyl)ethyl]acetamide 4 afforded N-acetyl-5-benzyloxy-6,8-dimethoxy- 1,3-trans-dimethyl-1,2,3,4-tetrahydroisoquinoline 3. The product was shown to exist as a mixture of rotamers by NMR spectroscopy, since signals coalesced at higher temperatures. 2-[2-[1-(Acetylamino)ethyl]-6-(benzyloxy)-3,5-dimethoxyphenyl]-1-methylethyl methanesulfonate 8 was also cyclized with sodium hydride to afford rotameric products with the same isoquinoline skeleton, but as a mixture of 1,3-cis- and transdimethyl isomers.