51074-13-6

Basic information

• Product Name: α-Benzoyl-α-(2-naphthyl) acetonitrile
• Synonyms: α-Benzoyl-α-(2-naphthyl) acetonitrile
• CAS NO: 51074-13-6
• Molecular Weight: 271.318
• Mol File: 51074-13-6.mol

Chemical Properties

• CAS DataBase Reference: α-Benzoyl-α-(2-naphthyl) acetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: α-Benzoyl-α-(2-naphthyl) acetonitrile(51074-13-6)
• EPA Substance Registry System: α-Benzoyl-α-(2-naphthyl) acetonitrile(51074-13-6)

Safety Data

• Hazardous Substances Data: 51074-13-6(Hazardous Substances Data)

Upstream product

• 7498-57-9 2-naphthaleneacetonitrile 
• 93-89-0 benzoic acid ethyl ester 

Relevant articles and documents

Asymmetric Transfer Hydrogenation of α-Substituted-β-Keto Carbonitriles via Dynamic Kinetic Resolution

A catalytic protocol for the enantio- and diastereoselective reduction of α-substituted-β-keto carbonitriles is described. The reaction involves a DKR-ATH process with the simultaneous construction of β-hydroxy carbonitrile scaffolds with two contiguous stereogenic centers. A wide range of α-substituted-β-keto carbonitriles were obtained in high yields (94%-98%) and excellent enantio- and diastereoselectivities (up to >99% ee, up to >99:1 dr). The origin of the diastereoselectivity was also rationalized by DFT calculations. Furthermore, this methodology offers rapid access to the pharmaceutical intermediates of Ipenoxazone and Tapentadol.