51082-27-0Relevant academic research and scientific papers
A Relay Strategy Actuates Pre-Existing Trisubstituted Olefins in Monoterpenoids for Cross-Metathesis with Trisubstituted Alkenes
Bahou, Karim A.,Braddock, D. Christopher,Meyer, Adam G.,Savage, G. Paul,Shi, Zhensheng,He, Tianyou
, p. 4906 - 4917 (2020/04/10)
A retrosynthetic disconnection-reconnection analysis of epoxypolyenes - substrates that can undergo cyclization to podocarpane-type tricycles - reveals relay-actuated Δ6,7-functionalized monoterpenoid alcohols for ruthenium benzylidene catalyzed olefin cross-metathesis with homoprenyl benzenes. Successful implementation of this approach provided several epoxypolyenes as expected (E/Z, ca. 2-3:1). The method is further generalized for the cross-metathesis of pre-existing trisubstituted olefins in other relay-actuated Δ6,7-functionalized monoterpenoid alcohols with various other trisubstituted alkenes to form new trisubstituted olefins. Epoxypolyene cyclization of an enantiomerically pure, but geometrically impure, epoxypolyene substrate provides an enantiomerically pure, trans-fused, podocarpane-type tricycle (from the E-geometrical isomer).
Prepackaged Ramberg-B?cklund reagents: Useful tools for organic synthesis
Block, Eric,Jeon, Hak Rim,Putman, David,Zhang, Shao-Zhong
, p. 7525 - 7541 (2007/10/03)
The synthesis and reactions of several α,β-unsaturated chloromethyl sulfones is presented, for example [(chloromethyl)sulfonyl]-1,3- propadiene (4), [(chloromethyl)sulfonyl]ethene (5), [(dichloromethyl)sulfonyl] ethene (6) and (E,Z)-1,2-bis[(chloromethyl)
NOVAL SYNTHESIS OF 1,3,5-TRISELENANES FROM ALDEHYDES, AND NOVEL GENERATION OF SELENOALDEHYDES BY FRAGMENTATION OF 1,3,5-TRISELENANES
Takikawa, Yuji,Uwano, Akira,Watanabe, Hiroyuki,Asanuma, Masaki,Shimada, Kazuaki
, p. 6047 - 6050 (2007/10/02)
Reaction of aldehydes with (Me3Si)2Se in the presence of Lewis acid afforded 1,3,5-triselenanes via selenoaldehydes.Novel and convenient generation of selenoaldehydes was also achived by thermally- or Lewia acid-induced fragmentation of 1,3,5-triselenanes.
