22824-34-6

Usage

Physical state

Colorless liquid

Odor

Strong, sweet

Usage

Fragrance ingredient in perfumes and personal care products

Usage

Solvent in industrial applications

Family

Tetrahydronaphthalene family

Classification

Aromatic hydrocarbon

Production method

Catalytic hydrogenation of naphthalene

Flammability

Known to be flammable

Health hazard

May cause irritation to skin and eyes upon contact

Upstream product

• 22184-00-5 2-(methyl-5-(4-methylphenyl))-2-pentanol 
• 4619-20-9 3-(4-methylbenzoyl)propionic acid 
• 108-88-3 toluene 
• 4521-22-6 4-(4-methylphenyl)butyric acid 
• 51082-27-0 1-methyl-4-(4-methylpent-3-en-1-yl)benzene 
• 24306-23-8 methyl 4-(4-methylphenyl)butanoate 
• 104-87-0 4-methyl-benzaldehyde 
• 4548-78-1 (3-methylbutyl)magnesium bromide 
• 73177-66-9 4-methyl-1-(4-methylphenyl)-1-pentanol 

Downstream Products

• 169124-30-5 methyl 4-<(3,5,5-trimethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl>benzoate 
• 98453-65-7 C₂₀H₂₂N₂O₂S 
• 169124-31-6 methyl 4-<(3,5,5-trimethyl-5,6,7,8-tetrahydronaphthalen-2-yl)ethenyl>benzoate 

Relevant academic research and scientific papers

BEXAROTENE DERIVATIVES AND THEIR USE IN TREATING CANCER

This disclosure relates to compositions and methods for treating cancer. Specifically, this disclosure relates to bexarotene derivatives, methods for treating cancer, autoimmune disorders, and/or skin dermatitis, and/or methods for increasing peripheral blood counts and/or improving immune system function.

ZnI2/Zn(OTf)2-TsOH: A versatile combined-Acid system for catalytic intramolecular hydrofunctionalization and polyene cyclization

A mild and efficient combined-Acid system using a zinc(ii) salt [ZnI2 or Zn(OTf)2] and p-Toluene sulfonic acid (TsOH) was investigated for catalytic cationic cyclizations, including intramolecular hydrocarboxylation, hydroalkoxylation, hydroamination, hydroamidation, hydroarylation and polyene cyclizations. This reaction provides easy access to five-and six-membered O-and N-containing saturated heterocyclic compounds, tetrahydronaphthalene derivatives and polycyclic skeletons in excellent yield with perfect Markovnikov selectivity and under mild conditions. The operational simplicity, broad applicability, and use of inexpensive commercially available catalysts make this protocol superior to existing methodologies.

RXR activating molecules

Disclosed are molecules that activate an RXR receptor, wherein the molecule comprises an RXR binding portion which binds the RXR receptor and comprises a side pocket contacting residue which contacts a side-pocket 1 of an RXR receptor.

Compositions and methods for treatment of hyperproliferative diseases

The invention relates to compositions comprising a retinoid X receptor agonist and an agent capable of activating protein kinase A. The invention also relates to methods of treating hyperproliferative diseases by administering a retinoid X receptor agonis

Retinoic acid receptor antagonists as promoters of angiogenesis

Methods and compositions for treating various disorders by administering a therapeutically effective amount of a retinoic acid receptor antagonist alone or in combination or in conjunction with other therapeutic agents to promote angiogenesis are provided

SUBSTITUENT EFFECTS ON THE RATE OF CARBENE FORMATION BY THE PYROLYSIS OF RIGID ARYL SUBSTITUTED DIAZOMETHANES

Rate constants for the pyrolysis of 1-diazo-4,4-dimethyl-1,4-dihydronaphtalenes, 4a-4e, have been measured in methanol:6percent triethylamine.In contrast to non-rigid cases, like diphenyldiazomethanes, where all para substituents show a rate increase compared to hydrogen, these rates show a linear Hammett correlation for all para substituents with ?+ = -0.84.This observation is rationalized by a non-linear process for loss of nitrogen leading directly to the ground-state singlet of the carbene, 17.This carbene is then trapped to give ether 11.