51086-32-9

Upstream product

• 804553-25-1 1-hydroxy-1-phenyl-3,4-dihydro-1H-naphthalin-2-one 
• 94051-93-1 1-phenyl-1,2,3,4-tetrahydronaphthalen-1-ol 
• 14578-74-6 3-Chloro-benzoic acid 1-hydroxy-1-phenyl-1,2,3,4-tetrahydro-naphthalen-2-yl ester 
• 7469-40-1 1-phenyl-3,4-dihydronaphthalene 

Downstream Products

• 14578-75-7 1-phenyl-3,4-dihydronaphthalen-2(1H)-one 

Relevant academic research and scientific papers

New chiral binaphthalene-derived iminium salt organocatalysts for asymmetric epoxidation of alkenes

(Chemical Equation Presented) A series of binaphthalene-fused azepinium salts has been generated and used as organocatalysts in the asymmetric epoxidation of unfunctionalized alkenes, giving rise to ees of up to 84%.

ASPARTYL PROTEASE INHIBITORS

Disclosed are compounds of formula I (Chemical formula should be inserted here as it appears on abstract in paper form) Formula I or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein R1, R2, R3, R4, R14, V, W, X, Y, Z, p, and ring A are as described in the specification. Also disclosed is the method of inhibiting aspartyl protease, and in particular, the methods of treating cardiovascular diseases, cognitive and neurodegenerative diseases. Also disclosed are methods of treating cognitive or neurodegenerative diseases using the compounds of formula I in combination with a cholinesterase inhibitor or a muscarinic m1 agonist or m2 antagonist.

A concise synthesis of 1-substituted-2-tetralones by selective diol dehydration leading to ketone transposition

Dehydration of 1-substituted-1,2-tetralindiols with zinc iodide afforded the corresponding 2-tetralones in excellent yields. This procedure was found to be superior to the more conventional BF3-catalyzed rearrangement of 1-substituted-1,2-epoxytetralins. (C) 2000 Elsevier Science Ltd.