51106-82-2Relevant academic research and scientific papers
Gold(I)-catalyzed synthesis of highly substituted furans
Suhre, Michael H.,Reif, Michael,Kirsch, Stefan F.
, p. 3925 - 3927 (2005)
(Chemical Equation Presented) Cationic triphenylphosphinegold(I) complexes are excellent catalysts for a cascade reaction of propargyl-Claisen rearrangement and heterocyclization to synthesize tri- and tetrasubstituted furans. Starting from easily accessed propargyl vinyl ethers, the furans are obtained in 72-99% yield.
Copper-catalyzed, silver-mediated formal [3+2] cycloaddition of simple alkynes with β-ketoesters through propargylic C(sp3)-H functionalization
Liu, Zhen-Ting,Hu, Xiang-Ping
supporting information, p. 14100 - 14103 (2019/01/03)
A copper-catalyzed propargylic [3+2] cycloaddition of simple alkynes with β-ketoesters through the propargylic C(sp3)-H functionalization has been realized. Under catalysis by CuI in combination with 1,10-phenanthroline hydrate as the ligand and Ag2CO3 as a bifunctional reagent (oxidant and base), the reaction proceeds smoothly with a broad substrate scope, thus providing a variety of highly functionalized furans in moderate to high yields. This represents the first successful example of the catalytic propargylic cycloaddition of simple alkynes with bisnucleophiles based on the propargylic C(sp3)-H functionalization strategy.
Method for preparing tetrasubstituted furan compound based on carbon-hydrogen bond activation
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Paragraph 0056; 0057; 0058; 0059-0097, (2019/01/08)
The invention provides a method for preparing a tetrasubstituted furan compound based on carbon-hydrogen bond activation, belongs to the field of organic synthesis, and relates to a method for synthesizing a tetrasubstituted furan compound through a [3+2]
Regioselective Access to Structurally Diverse Coumarin Analogues through Iron-Catalysed Annulation Reactions
Ren, Qiao,Kang, Jie,Li, Muyao,Yuan, Lujiang,Chen, Ruoyun,Wang, Lei
supporting information, p. 5566 - 5571 (2017/10/13)
A highly efficient iron-catalysed propargylation/alkyne oxacyclization/isomerization strategy is described. Biologically active furo[3,2-c]coumarins and pyrano[3,2-c]coumarins are expeditiously assembled in moderate to good yields and with a broad substrate scope. The regioselective access to different coumarins is mainly dependent on the terminal group of the secondary propargylic alcohol.
