51108-53-3Relevant academic research and scientific papers
A mild halogenation of pyrazoles using sodium halide salts and Oxone
Olsen, Kathryn L.,Jensen, Matthew R.,MacKay, James A.
supporting information, p. 4111 - 4114 (2017/09/29)
A mild, inexpensive, and operationally simple pyrazole halogenation method utilizing Oxone and sodium halide salts is reported. This work documents 17 examples of alkyl, aryl, allyl, and benzyl substituted 4-chloro and 4-bromopyrazoles, obtained in up to 93% yield. Reactions are performed in water under ambient conditions and generation of organic byproducts is avoided.
Rearrangement of N-(Alkylamino)azoles in Acid Media: A New Entry to C-Amino-N-substituted Azoles
Salazar, Loreto,Espada, Modesta,Avendano, Carmen,Claramunt, Rosa Maria,Sanz, Dionisia,Elguero, Jose
, p. 1563 - 1567 (2007/10/02)
A ring-opening / ring-closure mechanism for the thermal rearrangement of 1-(alkylamino)pyrazoles into 5-amino-1-alkylpyrazoles in acid medium has been established. 1-(Benzylamino)pyrazoles show a different reactivity, affording bis(5-amino-1-benzyl-4-pyrazolyl)phenylmethanes.The reaction was extended to 1-(alkylamino)indazoles but failed in the case of 1-(alkylamino)-1,2,4-triazoles.
