511231-16-6Relevant articles and documents
Synthesis of N-alkyl-N′-aryl-piperazines via copper-catalyzed C-N bond formation
Yavari, Issa,Bayat, Mohammad J.,Ghazanfarpour-Darjani, Majid
, p. 5595 - 5596 (2014/12/11)
An efficient copper-catalyzed tandem synthesis of N-alkyl-N′-aryl-piperazines from 1,4-diaza-bicyclo[2.2.2]octane, alkyl halides, and aryl halides in the presence of copper(I) iodide and potassium tert-butoxide in DMSO is described.
Scope and utility of CsOH·H2O in animation reactions via direct coupling of aryl halides and sec-alcyclic amines
Varala, Ravi,Ramu,Alam, M. Mujahid,Adapa, Srinivas R.
, p. 1747 - 1750 (2007/10/03)
Direct coupling of aryl halides with sec-alicyclic amines promoted by CsOH·H2O in DMSO to the corresponding aryl substituted amines, with good to excellent yields, is reported herein. A variety of aryl halides and sec-alicyclic amines with a broad range of electronic diversity and functional groups was studied in this transformation, thus offering general applicability in organic synthesis.