511231-16-6

Basic information

• Product Name: Piperazine, 1-(1-naphthalenyl)-4-(phenylmethyl)-
• CAS NO: 511231-16-6
• Molecular Formula: C21H22N2
• Molecular Weight: 302.419
• Mol File: 511231-16-6.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Piperazine, 1-(1-naphthalenyl)-4-(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Piperazine, 1-(1-naphthalenyl)-4-(phenylmethyl)-(511231-16-6)
• EPA Substance Registry System: Piperazine, 1-(1-naphthalenyl)-4-(phenylmethyl)-(511231-16-6)

Safety Data

• Hazardous Substances Data: 511231-16-6(Hazardous Substances Data)

Upstream product

• 57536-86-4 1-naphtylpiperazine 
• 100-44-7 benzyl chloride 
• 280-57-9 1,4-diaza-bicyclo[2.2.2]octane 
• 90-11-9 1-Bromonaphthalene 
• 100-39-0 benzyl bromide 
• 90-14-2 1-Iodonaphthalene 
• 2759-28-6 1-phenylmethylpiperazine 

Downstream Products

• 57536-86-4 1-naphtylpiperazine 

Relevant articles and documents

Synthesis of N-alkyl-N′-aryl-piperazines via copper-catalyzed C-N bond formation

An efficient copper-catalyzed tandem synthesis of N-alkyl-N′-aryl-piperazines from 1,4-diaza-bicyclo[2.2.2]octane, alkyl halides, and aryl halides in the presence of copper(I) iodide and potassium tert-butoxide in DMSO is described.

Scope and utility of CsOH·H2O in animation reactions via direct coupling of aryl halides and sec-alcyclic amines

Direct coupling of aryl halides with sec-alicyclic amines promoted by CsOH·H2O in DMSO to the corresponding aryl substituted amines, with good to excellent yields, is reported herein. A variety of aryl halides and sec-alicyclic amines with a broad range of electronic diversity and functional groups was studied in this transformation, thus offering general applicability in organic synthesis.