511255-41-7Relevant articles and documents
Analogs of the dopamine D4 receptor ligand FAUC 113 with planar- and central-chirality
Loeber, Stefan,Ortner, Birgit,Bettinetti, Laura,Huebner, Harald,Gmeiner, Peter
, p. 2303 - 2310 (2007/10/03)
By employing yeast enzymes, natural amino acids and the Jacobsen's catalyst as sources of chirality, we have synthesized pyrazolo[1,5-a]pyridine derivatives with central- and planar-chirality as analogs of the dopamine D4 receptor ligand FAUC 113. In vitro binding experiments displayed enhanced D2 and D3 affinity for both enantiomers of the [2.2]paracyclophane 3. The C-methylpiperazine (R)-4a revealed excellent D4 selectivity.