511274-75-2

Upstream product

• 13231-13-5 (2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)benzene 
• 604-69-3 β-D-glucose pentaacetate 
• 5627-22-5 (2R,3S,4R,5R,6S)-2-(hydroxymethyl)-6-phenyltetrahydro-2H-pyran-3,4,5-triol 
• 511274-47-8 (2R,4aR,6S,7R,8R,8aS)-2,6-Diphenyl-hexahydro-pyrano[3,2-d][1,3]dioxine-7,8-diol 
• 511274-41-2 (2R,4aR,6S,7S,8R,8aR)-7,8-Dimethoxy-2,6-diphenyl-hexahydro-pyrano[3,2-d][1,3]dioxine 
• 511274-72-9 (2R,3R,4S,5S,6S)-2-Hydroxymethyl-4,5-dimethoxy-6-phenyl-tetrahydro-pyran-3-ol 
• 21430-12-6 6-heptenoyl chloride 
• 572-09-8 2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl bromide 

Relevant academic research and scientific papers

A convergent ring-closing metathesis approach to carbohydrate-based macrolides with potential antibiotic activity

An efficient convergent approach has been developed for the construction of novel, non-natural, carbohydrate-based macrolides. The key step in the synthesis is the formation of the macrocyclic ring via a ring-closing metathesis reaction. The obtained macrolide analogues have been screened for biological activity against Gram-positive and Gram-negative bacteria, including resistant strains, yeasts, and molds.