511304-75-9Relevant academic research and scientific papers
Ligand-based design of a potent and selective inhibitor of cytochrome P450 2C19
Foti, Robert S.,Rock, Dan A.,Han, Xiaogang,Flowers, Robert A.,Wienkers, Larry C.,Wahlstrom, Jan L.
experimental part, p. 1205 - 1214 (2012/04/04)
A series of omeprazole-based analogues was synthesized and assessed for inhibitory activity against CYP2C19. The data was used to build a CYP2C19 inhibition pharmacophore model for the series. The model was employed to design additional analogues with inh
COMPOUNDS AND KITS FOR PREPARING IMAGING AGENTS AND METHODS OF IMAGING
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Page/Page column 15-16, (2008/06/13)
Compounds that include a targeting moiety bound to a regioselective leaving group are useful for preparing imaging agents. The imaging agents can be isolated from by-products derived from the leaving group based on differences in the chemical attributes (e.g., net charge or polarity) of the molecules or physical attributes of the molecules through the use of a solid support. Methods of producing an imaging agent include the steps of providing a compound that includes a targeting moiety bound to a support via a linker group that contains a site for regioselective substitution of a detectable species, contacting the compound with a solution containing the detectable species, and recovering the imaging agent. Kits which include a first container (5) having therein a solution (31) containing a detectable species and a second container (2) having therein a compound that includes a targeting moiety bound to a support (30) via a leaving group that contains a site for regioselective substitution of the detectable species are also useful for preparing imaging agents.
