51131-55-6

Basic information

• Product Name: 4-(2-amino-2-methylpropyl)aniline
• CAS NO: 51131-55-6
• Molecular Formula: C₁₀H₁₆N₂
• Molecular Weight: 164.2474
• Mol File: 51131-55-6.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 288.8°C at 760 mmHg
• Flash Point: 151.7°C
• Density: 1.018g/cm³
• Vapor Pressure: 0.00228mmHg at 25°C
• Refractive Index: 1.568
• CAS DataBase Reference: 4-(2-amino-2-methylpropyl)aniline(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-amino-2-methylpropyl)aniline(51131-55-6)
• EPA Substance Registry System: 4-(2-amino-2-methylpropyl)aniline(51131-55-6)

Safety Data

• Hazardous Substances Data: 51131-55-6(Hazardous Substances Data)

Usage

Chemical compound

4-(2-amino-2-methylpropyl)aniline

Derivative of

Aniline

Substituent

Propylamine on the amino group

Applications

Production of dyes, pharmaceuticals, rubber chemicals, reagent in organic synthesis, intermediate in manufacturing industrial products

Health hazards

Should be handled with caution

Upstream product

• 5440-67-5 2-(4-nitrobenzyl)-2-nitropropane 
• 122-09-8 Phentermin 
• 79-46-9 2-nitropropane 
• 100-14-1 4-nitrobenzyl chloride 
• 82408-64-8 N-(1,1-dimethyl-2-(4-nitrophenyl)ethyl)amine 
• 1197-21-3 phentermine hydrochloride 
• 108835-36-5 2-amino-2-methyl-1-(4-nitrophenyl)propane sulfate 

Downstream Products

• 143285-75-0 1-<2-(4-aminophenyl)-1,1-dimethylamino>-3-(4-acetamidophenoxy)propan-2-ol 
• 128232-11-1 5-<2-<<1-(4-iodophenyl)-2-methylprop-2-yl>amino>-1-hydroxyethyl>-8-hydroxycarbostyril 
• 85135-26-8 (+/-)-15-(4-azido-3-iodobenzyl)carazolol 
• 128232-09-7 8-Benzyloxy-5-{1-hydroxy-2-[2-(4-iodo-phenyl)-1,1-dimethyl-ethylamino]-ethyl}-1H-quinolin-2-one 
• 85135-25-7 (+/-)-15-(4-azidobenzyl)carazolol 
• 101639-67-2 1-<4-(2-cyclopropylmethoxyethyl)phenoxy>-3-<1-p-(aminophenyl)-2-methyl-2-propylamine>-2-propanol 
• 101639-66-1 1-<4-(2-cyclopropylmethoxyethyl)phenoxy>-3-<1-p-(azidophenyl)-2-methyl-2-propylamine>-2-propanol 
• 101639-65-0 1-(p-azidophenyl)-2-methyl-2-propylamine 
• 81530-23-6 1,1-dimethyl-2-(4-amino-3-iodophenyl)ethylamine 
• 96684-29-6 2-amino-2-methyl-1-(4-iodophenyl)propane 
• 143285-76-1 1-<2-(4-aminophenyl)-1,1-dimethylethylamino>-3-(4-carbamoylmethylphenoxy)propan-2-ol 
• 122-09-8 Phentermin 
• 198283-44-2 4-(β-isocyanato-isobutyl)-phenyl isocyanate 
• 1355183-58-2 C₂₃H₃₂N₂O₃ 

Relevant articles and documents

A multivalent approach to the discovery of long-acting β2- adrenoceptor agonists for the treatment of asthma and COPD

A multivalent approach was applied to the design of long-acting inhaled β2-adrenoceptor agonists. A series of dimeric arylethanolamines based on the short acting β2-adrenoceptor agonist albuterol were prepared, varying the nature and length of the linker between the basic nitrogens. None of the C2-symmetric dimers demonstrated increased potency, however dimer 5j, derived from 4-phenethylamine, was found to have increased binding potency in vitro relative to the parent monomer. Optimization of this structure led to the identification of 22 (milveterol) which demonstrates high potency in vitro and long duration of action in a guinea pig model of bronchoprotection.

Aryl aniline derivatives as beta2 adrenergic receptor agonists

The invention provides novel β2 adrenergic receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with β2 adrenergic

Cu2+/BH4- REDUCTION SYSTEM: SYNTHETIC UTILITY AND MODE OF ACTION

Cu2+/BH4- offers a mild, method of reduction for aromatic and aliphatic tertiary nitro groups.Its mode of action has been studied, in comparison with related reagents, by deuterium isotope experiments.