51144-98-0

Basic information

• Product Name: 1H-Pyrrole, 1-(4-chlorobenzoyl)-
• CAS NO: 51144-98-0
• Molecular Formula: C11H8ClNO
• Molecular Weight: 205.644
• Mol File: 51144-98-0.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 1H-Pyrrole, 1-(4-chlorobenzoyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrole, 1-(4-chlorobenzoyl)-(51144-98-0)
• EPA Substance Registry System: 1H-Pyrrole, 1-(4-chlorobenzoyl)-(51144-98-0)

Safety Data

• Hazardous Substances Data: 51144-98-0(Hazardous Substances Data)

Upstream product

• 109-97-7 pyrrole 
• 104-88-1 4-chlorobenzaldehyde 
• 122-01-0 4-chloro-benzoyl chloride 
• 5867-01-6 N,N-diallyl-4-chlorobenzamide 
• 696-59-3 cis,trans-2,5-dimethoxytetrahydrofuran 
• 619-56-7 4-chlorobenzamide 

Downstream Products

• 1126-46-1 Methyl 4-chlorobenzoate 
• 23694-47-5 N-(4-chlorobenzyl)-1H-pyrrole 

Relevant articles and documents

Direct C2-arylation ofN-acyl pyrroles with aryl halides under palladium catalysis

C2-arylation ofN-acyl pyrroles with aryl halides is developed for the first time using Pd(PPh3)4as a catalyst in combination with Ag2CO3under air, which allowed the application of a good compatibility catalytic system. This protocol provides a straightforward method for the preparation of valuable arylated pyrroles in moderate to good yields under the standard conditions with good substrate tolerance. Interestingly, whileN-benzoyl pyrroles reacted well, the use of substrates with a thiophene or furan ring indicated that the thiophene and furan rings are more reactive than pyrrole for the present catalytic system.

Synthesis of N -Sulfonyl- and N -Acylpyrroles via a Ring-Closing Metathesis/Dehydrogenation Tandem Reaction

N -Sulfonyl- and N -acylpyrroles were synthesized via olefin ring-closing metathesis of diallylamines and in situ oxidative aromatization in the presence of the ruthenium Grubbs catalyst and a suitable copper catalyst. In the presence of Cu(OTf) 2/s

Synthesis and nuclear magnetic resonance spectroscopic studies of 1- arylpyrroles

A series of m- and p-substituted 1-phenyl, 1-benzyl, 1-benzoyl, and 1- (2-phenylethyl)pyrroles was prepared and their 1H and 13C nmr spectroscopic characteristics were examined. In general, good correlations were observed between the chemical shift values of the β-H and the β-C of pyrroles [except 1-(2-phenylethyl)pyrroles] and the Hammettt σ. The observation may be explained in terms of the electronic effects of the substituents which are transmitted through bonds and through space by interaction of the p orbitals between β-Cs of the pyrrole ring and m- and p- Cs of the phenyl ring. Substituent constants of 1-pyrrolyl, 1-pyrrolylmethyl, and 1-pyrroloyl groups for the 1H and 13C chemical shifts of phenyl ring are also presented.