51146-63-5Relevant academic research and scientific papers
Inhibitions of monoamine oxidases and acetylcholinesterase by 1-methyl, 5-phenyl substituted thiosemicarbazones: Synthesis, biochemical, and computational investigations
Jayanthi, Sivaraman,Kim, Hoon,Kumar, Kumudhavalli Suresh,Mathew, Bijo,Mathew, Githa Elizabeth,Mohan, Kumar,Oh, Jong Min
, p. 246 - 253 (2020/10/02)
A series of eleven 1-methyl, 5-phenyl substituted thiosemicarbazones (MT1–MT11) with the phenyl ring substitutions were prepared and investigated for their inhibitory activities against monoamine oxidases (MAOs) and acetylcholinesterase (AChE). [4-(dimeth
Synthesis of 2-Hydrazolyl-4-Thiazolidinones Based on Multicomponent Reactions and Biological Evaluation Against Trypanosoma Cruzi
Pizzo, Chiara,Saiz, Cecilia,Talevi, Alan,Gavernet, Luciana,Palestro, Pablo,Bellera, Carolina,Blanch, Luis Bruno,Benitez, Diego,Cazzulo, Juan J.,Chidichimo, Agustina,Wipf, Peter,Mahler, S. Graciela
experimental part, p. 166 - 172 (2012/02/01)
A series of 18 novel 2-hydrazolyl-4-thiazolidinones-5-carboxylic acids, amides and 5,6-α,β-unsaturated esters were synthesized, and their in vitro activity on cruzipain and T. cruzi epimastigotes was determined. Some agents show activity at 37μm concentration in the enzyme assay. Computational tools and docking were used to correlate the biological response with the physicochemical parameters of the compounds and their cruzipain inhibitory effects.
Semicarbazones from N-hydroxyureas and amines: A novel entry in the reactivity of the acyl nitroso group
Paz, Jairo,Perez-Balado, Carlos,Iglesias, Beatriz,Munoz, Luis
supporting information; experimental part, p. 1800 - 1803 (2011/06/10)
The condensation of carbamoyl nitroso compounds, obtained by oxidation of N-hydroxyureas, with amines unexpectedly afforded semicarbazones (aka carbamoyl hydrazones). Although the substitution of the nitrosyl moiety might compete to afford the correspondi
The key role of sulfur in thiosemicarbazone compounds. Crystal and molecular structure of [Pd{4-MeOC6H4C(Me)=NN=C(S)NHPh}2]
Vila, José M.,Pereira, Teresa,Amoedo, Adriana,Gra?a, María,Martínez, Javier,López-Torres, Margarita,Fernández
, p. 176 - 184 (2007/10/03)
The reaction of thiosemicarbazones 4-MeOC6H4C(H)=NN(H)C(=S)NHMe (a), 4-MeOC6H4C(H)=NN(H)C(=S)NHEt (b) and 4-MeOC6H4C(H)=NN(H)C(=S)NHPh (c), with Li2[PdCl4], K2/s
Novel synthesis of new 5,7-disubstituted-2-alkyl/arylamino-4H-pyrazolothiadiazines and 4,6-disubstituted-3-amino/anilino-2-alkyl/aryliminopyrazolothiazolines
Chande, Madhukar S.,Joshi, Rajesh D.
, p. 289 - 301 (2007/10/02)
The title compounds have been prepared by the interaction of substituted 4-bromopyrazolin-5-ones with thiosemicarbazides.An alternate unambiguous synthesis of pyrazolothiazolines has been described.All the compounds have been characterised by spect
