511531-59-2Relevant academic research and scientific papers
POCHOXIME CONJUGATES USEFUL FOR THE TREATMENT OF HSP90 RELATED PATHOLOGIES
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Page/Page column 75, (2012/05/05)
The present invention includes novel derivatives, analogs, and intermediates of the natural products radicicol, pochonins, pochoximes, and their syntheses. The present invention also provides a pharamceutical composition comprising the present compound an
Asymmetric synthesis of pochonin e and F, revision of their proposed structure, and their conversion to potent Hsp90 inhibitors
Karthikeyan, Ganesan,Zambaldo, Claudio,Barluenga, Sofia,Zoete, Vincent,Karplus, Martin,Winssinger, Nicolas
supporting information; experimental part, p. 8978 - 8986 (2012/10/08)
A concise and modular synthesis of pochonin E and F, and their epimers at C-6 established the correct stereochemistry of these two natural products. Several members of the pochonin family have been shown to bind the heat shock protein 90 (Hsp90), which has been the focus of intense drug discovery efforts. Pochonin E and F as well as their epimers were derivatized into the corresponding pochoximes and further modified at the C-6 position. Molecular dynamics simulations, docking studies, and Hsp90 affinity measurements were performed to evaluate the impact of these modifications.
Synthesis of pochoxime prodrugs as potent HSP90 inhibitors
Wang, Cuihua,Barluenga, Sofia,Koripelly, Girish K.,Fontaine, Jean-Gonzague,Chen, Ruihong,Yu, Jin-Chen,Shen, Xiaodong,Chabala, John C.,Heck, James V.,Rubenstein, Allan,Winssinger, Nicolas
supporting information; experimental part, p. 3836 - 3840 (2010/04/05)
Pochoximes are potent inhibitors of heat shock protein 90 (HSP90) based on the radicicol pharmacophores. Herein we present a pharmacokinetics and pharmacodynamics evaluation of this compound series as well as a phosphate prodrug strategy to facilitate for
