511538-85-5Relevant academic research and scientific papers
Design, synthesis, and SAR of N-((1-(4-(propylsulfonyl)piperazin-1-yl) cycloalkyl)methyl)benzamide inhibitors of glycine transporter-1
Cioffi, Christopher L.,Wolf, Mark A.,Guzzo, Peter R.,Sadalapure, Kashinath,Parthasarathy, Visweswaran,Dethe, Dattatraya,Maeng, Jun-Ho,Carulli, Edmund,Loong, David T.J.,Fang, Xiao,Hu, Min,Gupta, Priya,Chung, Mark,Bai, Mei,Moore, Nick,Luche, Michele,Khmelnitsky, Yuri,Love, Patrick L.,Watson, Megan A.,Mhyre, Andrew J.,Liu, Shuang
, p. 1257 - 1261 (2013/03/14)
The design, synthesis, and structure-activity relationships (SAR) of a series of N-((1-(4-(propylsulfonyl)piperazin-1-yl)cycloalkyl)methyl)benzamide inhibitors of glycine transporter-1 (GlyT-1) are described. Optimization of the benzamide and central ring
Privileged structure based ligands for melanocortin receptors-4,4-Disubstituted piperidine derivatives
Kuklish, Steven L.,Backer, Ryan T.,Briner, Karin,Doecke, Christopher W.,Husain, Saba,Mullaney, Jeffrey T.,Ornstein, Paul L.,Zgombick, John M.,O'Brien, Thomas P.,Fisher, Matthew J.
, p. 3843 - 3846 (2007/10/03)
Homologation and cyclization back to the chiral methine of compound 3 yields achiral 4,4-disubstituted piperidine privileged structures (e.g., 8a) useful in the construction of melanocortin 4 receptor (MC4R) ligands. The piperidine nitrogen was replaced w
