511542-10-2Relevant academic research and scientific papers
Divergent synthesis of D-erythro-sphingosine, L-threo-sphingosine, and their regioisomers
Olofsson, Berit,Somfai, Peter
, p. 2514 - 2517 (2007/10/03)
Starting from a vinyl epoxide, a divergent synthesis of four sphingosine isomers is described. The remaining four isomers can easily be synthesized using the same methodology. Although numerous syntheses of sphingosine have been published, this is the first general route leading to all eight isomers in this important compound class. The synthetic strategy relies on regioselective opening of a vinyl epoxide and a vinylaziridine in the allylic position.
