51170-24-2Relevant academic research and scientific papers
Novel pyrrolidine-2,4-dione derivatives containing pharmacophores of both hydrazine and diphenyl ether as potential antifungal agents: Design, synthesis, biological evaluation, and 3D-QSAR study
Hu, Hao-Ran,Wang, An,Qiu, Ling-Ling,Wang, Xiao-Bin,Chen, Min,Lu, Ai-Min,Yang, Chun-Long
, p. 20071 - 20082 (2020)
In order to screen novel fungicide leads, 19 pyrrolidine-2,4-dione derivatives containing the pharmacophores of both hydrazine and diphenyl ether were designed, synthesized, and characterized by FT-IR, 1H NMR, 13C NMR, and HR-MS. The obtained target compo
Access to α-Amino Acid Esters through Palladium-Catalyzed Oxidative Amination of Vinyl Ethers with Hydrogen Peroxide as the Oxidant and Oxygen Source
Ouyang, Lu,Li, Jianxiao,Zheng, Jia,Huang, Jiuzhong,Qi, Chaorong,Wu, Wanqing,Jiang, Huanfeng
supporting information, p. 15926 - 15930 (2017/11/23)
A novel and convenient palladium catalytic system for the synthesis of α-amino acid esters from simple starting materials is reported. Hydrogen peroxide not only acts as the green oxidant, but also as the oxygen source. This strategy for the conversion of amines and vinyl ethers into highly functionalized and structurally diverse α-amino acid esters is characterized by the simplicity of the experimental procedure, mild reaction conditions, high atom economy, scalability, and practicability.
Design and synthesis of novel hydantoin-containing melanin-concentrating hormone receptor antagonists
Balavoine, Fabrice,Malabre, Patrice,Alleaume, Thierry,Rey, Astrid,Cherfils, Valerie,Jeanneton, Olivier,Seigneurin-Venin, Sophie,Revah, Frederic
, p. 3754 - 3759 (2008/02/10)
We report here new chemical series acting as antagonists of melanin-concentrating hormone receptor 1 (MCHR-1). Synthesis and structure-activity relationships are described leading to the identification of compounds with optimized in vitro pharmacological and in vitro ADME profiles. In vivo activity has been demonstrated in animal models of food intake and depression.
Synthesis of New 3-(Phenoxyphenyl)sydnones
Sindler-Kulyk, Marija,Jakopcic, Kresimir,Mance, Ana Dunja
, p. 1013 - 1015 (2007/10/02)
The title compounds were prepared by dehydrocyclization of corresponding substituted N-nitrosoglycines obtained from isomeric o-, m- and p-aminodiphenyl ether with ethyl bromoacetate and subsequent nitrosation of the intermediate N-arylsubstituted glycine
Angiotensin converting enzyme inhibitors: N-substituted monocyclic and bicyclic amino acid derivatives
Stanton,Gruenfeld,Babiarz,Ackerman,Friedmann,Yuan,Macchia
, p. 1267 - 1277 (2007/10/02)
The synthesis of N-(3-mercaptopropionyl)-N-arylglycines (14a-x), -N-arylalanines (15a,b), -N-cycloalkylglycines (16a-k), and -1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids (17a-d), -1,2,3,4-tetrahydroquinoline-2-carboxylic acids (18a-f), and -indoline-2-carboxylic acids (19a-k) is described. In vitro inhibition of angiotensin converting enzyme (ACE) is reported for each compound, and the structure-activity relationship for each series is discussed. The in vivo inhibition of ACE and antihypertensive effects of representative compounds from each series are discussed. The most potent compound, 19d, had an in vitro ACE IC50 of 2.6 x 10-9 M and lowered blood pressure in spontaneous hypertensive rats 85 mm at a dose of 10 mg/kg po.
