51177-07-2Relevant academic research and scientific papers
Stereoselective Synthesis of Verruculogen TR-2 Featuring the Mild Formation of a Dihydro-β-carboline as an Intermediate
Hermkens, Pedro H. H.,Plate, Ralf,Kruse, Chris G.,Scheeren, Hans W.,Ottenheijm, Harry C. J.
, p. 3881 - 3887 (2007/10/02)
Reaction of indolyldiketopiperazine 5 with 2,3,4,5,6,6-hexachlorocyclohexadien-1-one (25) in dichloromethane/methanol provided the methoxyindolenine 29, which in the presence of TFA rearranged to the dehydrodiketopiperazine 6.This compound was elaborated
First Total Synthesis of (-)-Verruculogen TR-2
Hermkens, Pedro H. H.,Plate, Ralf,Ottenheijm, Harry C. J.
, p. 1323 - 1324 (2007/10/02)
The total synthesis of the tremorgenic mycotoxin Verruculogen TR-2 (6) is presented.Selective oxidation of 1 to yield 3 or 4 was achieved using 2.Compound 4 was elaborated to the title compound employing osmium tetroxide.
