51212-36-3

Upstream product

• 14371-10-9 (E)-3-phenylpropenal 
• 1068-90-2 2-acetylaminomalonic acid diethyl ester 
• 3005-63-8 1-acetyl-5-hydroxy-3-phenyl-pyrrolidine-2,2-dicarboxylic acid diethyl ester 

Downstream Products

• 1015005-30-7 1-acetyl-3-phenylproline 
• 1426559-89-8 C₁₁H₁₃NO₂*ClH 
• 143979-44-6 1-(tert-butoxycarbonyl)-3-phenylproline 
• 1243146-85-1 (2R,3R)-1-tert-butyl 2-methyl 3-phenylpyrrolidine-1,2-dicarboxylate 
• 731810-63-2 (2R,3R)-N-(tert-butoxycarbonyl)-β-phenylproline 
• 462124-94-3 (2S,3S)-1-(tert-butoxycarbonyl)-3-phenylpyrrolidine-2-carboxylic acid 
• 212612-57-2 methyl (2S,3R)-N-(tert-butoxycarbonyl)-β-phenylprolinate 
• 1426559-88-7 methyl (2R,3S)-N-(tert-butoxycarbonyl)-β-phenylprolinate 
• 123724-21-0 (2S,3R)-1-(tert-butoxycarbonyl)-3-phenylpyrrolidine-2-carboxylic acid 
• 515173-98-5 (2S,3S)-3-phenyl-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester 
• 246869-32-9 3-Phenyl-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester 
• 771452-35-8 3-Phenyl-pyrrolidine-2-carboxylic acid methyl ester 
• 123724-32-3 (2R,3S)-1-(tert-butoxycarbonyl)-3-phenylpyrrolidine-2-carboxylic acid 
• 212061-79-5 1-Acetyl-3-phenyl-pyrrolidine-2,2-dicarboxylic acid ethyl ester 

Relevant academic research and scientific papers

Access to enantiomerically pure cis- and trans-β-phenylproline by high-performance liquid chromatography resolution

The preparation of all four stereoisomers of the proline analog that bears a phenyl group attached to the β carbon either cis or trans to the carboxylic acid (cis- and trans-β-phenylproline, respectively) has been addressed. The methodology developed allows access to multigram quantities of the target amino acids in enantiomerically pure form and suitably protected for use in peptide synthesis. Racemic precursors of cis-β-phenylproline and trans-β-phenylproline were prepared from easily available starting materials and subjected to high-performance liquid chromatography enantioseparation. Semipreparative columns (250 × 20 mm) containing chiral stationary phases based on amylose (Chiralpak IA) (Daicel-Chiral Technologies Europe, Illkirch, France) or cellulose (Chiralpak IC) were used respectively for the resolution of the cis- and trans-β-phenylproline precursors. Chirality, 24:1082-1091, 2012. 2012 Wiley Periodicals, Inc. Copyright

PIPERIDINE AND PYRROLIDINE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE

The present invention is directed to compounds of formula (I) which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.

Boronic ester and acid compounds, synthesis and uses

Disclosed herein are boronic ester and acid compounds, their synthesis and uses. More specifically, disclosed herein is a method for reducing the rate of degradation of proteins in an animal comprising contacting cells of the animal with certain boronic ester and acid compounds.

A convenient synthetic route to macrocyclic cis-3-phenylproline derivatives as mimics of Sandostatin

Enantiomerically pure 14- and 20-membered cyclic proline derivatives 2a- d were conveniently prepared from cis-3-phenylproline using macrolactonisation or macrolactamisation reactions.

BORONIC ESTER AND ACID COMPOUNDS

Disclosed herein is a method for reducing the rate of degradation of proteins in an animal comprising contacting cells of the animal with certain boronic ester and acid compounds. Also disclosed herein are novel boronic ester and acid compounds, their synthesis and uses.

Synthesis of 3-substituted 2,3-dehydroprolines: Oxidative decarboxylation of ethyl hydrogen acetoamidomalonate derivatives

A new synthetic method for α,β-dehydroamino acid derivatives have been accomplished via lead(IV) tetraacetate oxidation of ethyl hydrogen acetoamidomalonate derivatives in the presence of copper(II) acetate. Four 3-substituted 2,3-dehydroprolines have bee