512184-96-2 Usage
Uses
1. Used in Chemical Synthesis:
Boron, [m-[bis(1,1-dimethylethyl)[[(R)-(1,1-dimethylethyl)methylphosphino-kP]m ethyl]phosphine-kP]]hexahydrodiis used as a precursor in the synthesis of P-stereogenic bisphosphine ligands. These ligands are essential in various chemical reactions, particularly in asymmetric catalysis, where they can help achieve high levels of enantioselectivity and stereocontrol.
2. Used in Pharmaceutical Industry:
In the pharmaceutical industry, Boron, [m-[bis(1,1-dimethylethyl)[[(R)-(1,1-dimethylethyl)methylphosphino-kP]m ethyl]phosphine-kP]]hexahydrodimay be utilized as a key intermediate in the development of novel drugs with specific biological activities. The unique stereochemistry and structural features of Boron, [m-[bis(1,1-dimethylethyl)[[(R)-(1,1-dimethylethyl)methylphosphino-kP]m ethyl]phosphine-kP]]hexahydrodi- can be exploited to design and synthesize new pharmaceutical agents with improved efficacy and selectivity.
3. Used in Material Science:
Boron, [m-[bis(1,1-dimethylethyl)[[(R)-(1,1-dimethylethyl)methylphosphino-kP]m ethyl]phosphine-kP]]hexahydrodimay also find applications in the field of material science, where it could be used to develop new materials with specific properties. For instance, its incorporation into polymers or other materials could lead to the creation of materials with enhanced mechanical, thermal, or electrical properties.
4. Used in Research and Development:
Boron, [m-[bis(1,1-dimethylethyl)[[(R)-(1,1-dimethylethyl)methylphosphino-kP]m ethyl]phosphine-kP]]hexahydrodican be a valuable tool in academic and industrial research settings. Its unique structure and properties make it an interesting subject for studying fundamental chemical reactions, exploring new synthetic methodologies, and understanding the relationship between molecular structure and reactivity.
Check Digit Verification of cas no
The CAS Registry Mumber 512184-96-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 5,1,2,1,8 and 4 respectively; the second part has 2 digits, 9 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 512184-96:
(8*5)+(7*1)+(6*2)+(5*1)+(4*8)+(3*4)+(2*9)+(1*6)=132
132 % 10 = 2
So 512184-96-2 is a valid CAS Registry Number.
512184-96-2Relevant academic research and scientific papers
C1-symmetric bisphosphine ligands and their use in the asymmetric synthesis of pregabalin
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Page/Page column 15-16, (2008/06/13)
Materials and methods for preparing (S)-(+)-3-(aminomethyl)-5-methyl-hexanoic acid and structurally related compounds via enantioselective hydrogenation of prochiral olefins are disclosed. The methods employ novel chiral catalysts, which include C1-symmetric bisphosphine ligands bound to transition metals.
Highly Selective Asymmetric Hydrogenation Using a Three Hindered Quadrant Bisphosphine Rhodium Catalyst
Hoge, Garrett,Wu, He-Ping,Kissel, William S.,Pflum, Derek A.,Greene, Derek J.,Bao, Jian
, p. 5966 - 5967 (2007/10/03)
A concise synthesis of both enantiomers of ligand 2 and rhodium complex 5 is presented. The crux of the synthesis is a chiral HPLC separation of the enantiomers of 4. Rhodium complex 5 possesses three hindered quadrants in the steric environment within which a substrate binds. Evidence is presented that this configuration leads to high enantioselectivity (>99% ee) for rhodium-catalyzed asymmetric hydrogenation of α-acetamido dehydroamino acids, 6a-e. High enantioselectivities are also reported for the hydrogenation of a substrate precursor, 8, of pharmaceutical candidate, pregabalin. Advantages for large-scale hydrogenation of 8 using catalyst 5a vs Rh-Me-DuPhos are discussed. Copyright
