512186-59-3

Upstream product

• 333754-19-1 (1S,2S,3R,4S,5R,8R,9S,10R,13S)-4-(acetoxy)-2-(benzoyloxy)-1,13-dihydroxy-5,20-epoxy-9,10-[(1S)-2-propenylidenedioxy]tax-11-ene 
• 512186-58-2 3-(tert-butyl-dimethyl-silanyloxy)-3-methyl-2-oxo-4-pyridin-2-yl-azetidine-1-carboxylic acid tert-butyl ester 
• 512186-57-1 (3R,4S)-3-(tert-Butyl-dimethyl-silanyloxy)-3-methyl-4-pyridin-2-yl-azetidin-2-one 
• 184586-81-0 (1S,2S,3R,4S,5R,8R,9S,10R,13S)-4-(acetoxy)-2-(benzoyloxy)-5,20-epoxy-1,9,10,13-tetrahydroxytax-11-ene 
• 24424-99-5 di-tert-butyl dicarbonate 

Relevant academic research and scientific papers

New highly active taxoids from 9beta-dihydrobaccatin-9,10-acetals. Part 3.

We synthesized novel water-soluble and orally active taxane analogues, 7-deoxy-9beta-dihydro-9,10-O-acetal taxanes. Cytotoxicities of the synthetic compounds were greater than those of paclitaxel and docetaxel, especially against resistant cancer cell lines expressing P-glycoprotein. In addition, some compounds showed potent antitumor effects against B16 melanoma BL6 in vivo by both iv and po administration.