51224-12-5

Upstream product

• 17996-12-2 N-benzyloxycarbonyl-6-amino-1-hexanol 
• 98-59-9 p-toluenesulfonyl chloride 
• 501-53-1 benzyl chloroformate 
• 4048-33-3 6-amino-1-hexanol 

Downstream Products

• 1246368-46-6 N-[6-(benzyloxycarbonylamino)hexyl]-1,5-dideoxy-1,5-imino-D-galactitol 
• 116701-39-4 methyl N⁴-<6-<<(phenylmethoxy)carbonyl>amino>-1-hexyl>-N⁴-(2',3'-O-isopropylidene-5'-adenosyl)-2(R,S)-(trifluoroacetamido)-4-aminobutyrate 
• 116701-41-8 N⁴-<6-<<(phenylmethoxy)carbonyl>amino>-1-hexyl>-N⁴-(2',3'-O-isopropylidene-5'-adenosyl)-2(R,S),4-diaminobutanoic acid 
• 116700-91-5 5'-<<6-<<(phenylmethoxy)carbonyl>amino>-1-hexyl>amino>-5'-deoxy-2',3'-O-isopropylideneadenosine 
• 528840-32-6 4,7-N,N-di-tert-butyloxycarbonyl-1-N-[6-(N-benzyloxycarbonyl)aminohexyl]-1,4,7-triazacyclononane 
• 957829-63-9 10-(6-benzyloxycarbonylamino-hexyl)-1,4,7,10-tetraaza-cyclododecane-1,4,7-tricarboxylic acid tri-tert-butyl ester 
• 51224-11-4 6-(benzyloxycarbonylamino)-1-iodohexane 

Relevant academic research and scientific papers

ACRIDIN-9-YL-AMINE, QUINOLIN-9-YL-AMINE, 1 -AMINO-9H-THIOXANTHENE-9-ONE AND BENZO[B][1,5]NAPHTHYRI DIN-10-YL-AMINE DERIVATIVES AS AUTOPHAGY INHIBITORS FOR TREATING CANCER

This disclosure provides a cridin-9-yl-amine, quinolin-9-yl-amine, 1- amino-9H-thioxanthene-9-one and benzo[b][l,5]naphthyridin-10- yl-amine derivatives and structurally related compounds for use as autophagy inhibitors for treating cancer. The present description discloses the synthesis and characterisation of exemplary compounds as well as pharmacological data thereof (e.g. pages 77 to 155; examples 1 to 22; compound A; compounds 1 to 21; tables 1 to 3).

Effective methods for the biotinylation of azamacrocycles

(Chemical Equation Presented) The biotin-(strept)avidin interaction remains a gold standard of model biological recognition events. The biotinylation of azamacrocycles permits the investigation of signal transduction between this recognition event and the