51229-68-6

Upstream product

• 7605-30-3 ethyl 2-phenylsulfonylacetate 
• 129112-26-1 2-iodophenyltrifluoromethanesulfonic acid 
• 51229-70-0 (o-Ethoxycarbonyl-α-jod-benzyl)-phenyl-sulfon 
• 51229-69-7 (o-Ethoxycarbonyl-α-brom-benzyl)-phenyl-sulfon 
• 1531-78-8 o-(chloromethyl)benzoic acid ethyl ester 
• 873-55-2 sodium benzenesulfonate 

Downstream Products

• 41037-91-6 (o-Carboxy-α-jod-benzyl)-phenyl-sulfon 
• 41037-90-5 (o-Carboxy-α-brom-benzyl)-phenyl-sulfon 
• 51229-70-0 (o-Ethoxycarbonyl-α-jod-benzyl)-phenyl-sulfon 
• 51229-69-7 (o-Ethoxycarbonyl-α-brom-benzyl)-phenyl-sulfon 

Relevant academic research and scientific papers

Acylalkylation of Arynes Generated from o-Iodoaryl Triflates with Hydrosilanes and Cesium Fluoride

An efficient method to generate aryne intermediates from o-iodoaryl triflates triggered by triethylsilane and cesium fluoride is disclosed. This method realized the acylalkylation of arynes using easily available o-iodoaryl triflate-type precursors, which was difficult when using conventional nucleophilic activators. A wide range of (hetero)arenes including various fused benzothiazoles were successfully synthesized from o-iodoaryl triflates by virtue of their good accessibility and divergent transformations of aryne intermediates.

A novel multicomponent reaction of arynes, β-keto sulfones, and Michael-type acceptors: A direct synthesis of polysubstituted naphthols and naphthalenes

(Chemical Equation Presented) A novel multicomponent reaction of arynes, β-keto sulfones, and Michael-type acceptors is presented, providing an efficient method for the synthesis of polysubstituted naphthols and polysubstituted naphthalenes. Further investigation suggests that the tandem reaction may proceed via a sequential nucleophilic attack to arynes, intramolecular nucleophilic substitution followed by a Michael addition, and a ring closure - elimination process.