51234-85-6

Usage

Uses

Used in Pharmaceutical Industry:
2-(4-Chlorophenyl)-5-benzoxazoleacetic Acid is used as an active pharmaceutical ingredient for its anti-inflammatory activity. It is particularly effective in reducing inflammation and pain associated with various conditions, making it a valuable compound in the development of new medications.
Used in Chemical Research:
As a derivative of Benoxaprofen, 2-(4-Chlorophenyl)-5-benzoxazoleacetic Acid can also be used in chemical research to study the structure-activity relationship of related compounds and to develop new drugs with improved properties.
Used in Material Science:
The pink solid nature of 2-(4-Chlorophenyl)-5-benzoxazoleacetic Acid may have potential applications in material science, particularly in the development of pigments or dyes for various industries, such as textiles, plastics, and coatings.

InChI:InChI=1/C15H10ClNO3/c16-11-4-2-10(3-5-11)15-17-12-7-9(8-14(18)19)1-6-13(12)20-15/h1-7H,8H2,(H,18,19)

Upstream product

• 827-72-5 4-chlorobenzimidic acid ethyl ester 
• 38196-08-6 4-hydroxy-3-amino-phenylacetic acid 
• 10463-20-4 4-hydroxy-3-nitrophenylacetic acid 

Downstream Products

• 1391054-57-1 (+/-)2-(4-chlorophenyl)-α-methyl-5-benzoxazoleacetic acid 

Relevant academic research and scientific papers

A FACILE SYNTHESIS OF(+/-) 2-(4-CHLOROPHENYL)-α-METHYL-5-BENZOXAZOLACETIC ACID (BENOXAPROFEN)

A convenient four step procedure for the synthesis of benoxaprofen is described starting with 4-hydroxyphenylacetic acid.

2-Phenyl-5-benzoxazolylalkanoic acid purification process

Crude preparations of 2-phenyl-5-benzoxazolylalkanoic acids are purified by forming the ammonium salt thereof in an organic solvent and thermally reconverting the separated ammonium salt to the acid. Gaseous ammonia is a by-product.

2-(Optionally substituted)phenyl-5 or 6-substituted benzoxazoles

2-(Optionally substituted)phenyl-benzoxazoles having a carboxy alkyl, a tetrazolyl, or oxazolinyl group at the 5 or 6 position useful as aspirin-like non-steroidal, non-narcotic, analgesic, antipyretic and anti-inflammatory agents.

Benzoxazole derivatives in treating inflammation, pain and fever

The invention provides novel 5- and 6-benzoxazolyl alkanoic acids, optionally substituted in the 2-position, and derivatives thereof which possess anti-inflammatory, anti-pyretic and analgesic activity. Also provided is a process for preparing such compounds by cyclising an appropriately substituted o-aminophenol and, if necessary, converting the resultant benzoxazole to the desired compound.