51235-04-2 Usage
Chemical Properties
The pure product is white crystalline solid. m.p.115～117℃. Vapour pressure is 2.7×10-3Pa (25℃)、8.5×10-3Pa (86℃). Relative density is 1.25. The solubility at 25 ℃: 3880g/kg in chloroform, 2650g/kg in methanol, 836g/kg in dimethylformamide,790g/kg in acetone, 940g/kg in benzene, 386g/kg in toluene, 3g/kg in hexane and 33g/kg in water. In the water solution with pH value of 5~9, it is stable at normal temperature and will be decomposed by microbes in the soil.
Uses
Different sources of media describe the Uses of 51235-04-2 differently. You can refer to the following data:
1. Post bud contact killing herbicide and the inhibitor of photosynthesis in plants. Its weed killing spectrum and killing shrub spectrum are wide, and its toxicity is strong and effective. It is used for tending young forests of evergreen coniferous forests, such as Pinus koraiensis, Pinus sylvestris, Picea spruce, Pinus massoniana and so on. Before the afforestation, it is applied to weeding and extinguishing irrigation, maintaining and opening forest fire prevention and forest soil improvement etc...It can also be used for weeding and irrigation on both sides of the oil depot, airport and road. It can prevent green bristlegrass, filipendula palmate, angelica dahurica,sedge, herba elsholtziae, reed, deyeuxia angustifolia, fern, clematis, veronica spuria, cephalanoplos segetum, wild oats, quinoa, millet, etc.. The woody plants it can can control include yellow lonicera japonica, pearl, hazel wood, spiraea salicifolia, acanthopanax senticosus, acanthopanax, winged elm, aspen, birch, quercus mongolica, linden, oak, linden, ashtree, phellodendron amurense rupr, juglans mandshurica etc.. It can control annual weed and biennial weed. A dose of 2～5kg/hm2 control weeds for a short term. Most perennial weeds can be prevented by the dose of 6～12kg/hm2. Nonionic surfactants can be added to this product.
2. Herbicide.
3. Hexazinone is a triazine compound used as a preemergence or postemergence herbicide to control many annual grasses and broad-leaved weeds in noncropped land and certain crops such as alfalfa, blueberries, coffee, pecans and sugarcane
Mechanism of action
It mainly inhibits the photosynthesis of plants and causes the disordered generation of plants and causes death. Both plant root and leaf surface can absorb the cyclohexanone, which is transported mainly through the xylem. It has great mobility in the soil and can be decomposed by soil microbes after entering the soil. It has no harm to the root of the pine tree. 7 days after the weeds have been treated, the leaves will have necrosis until the whole leaf has withered. The whole process including the upper part above ground (about 2 weeks) and the rotting of the root lasts for 1 month. It will last for 1 month from the appearance of necrosison the new leaves to rotting roots of the shrubs lasts for about 2 months. The first defoliation of non - objective arbor takes place 20~30 days after the injury. In the future, the new born leaves will be molted again, repeating 3~5 times in a row. From the spot to the formation of shrub leaf rot lasted for about 2 months. The upper part of the ground dies in 60~120 days. The roots rot in the fall of second.
Toxicity
The drug is of toxicity when acute oral LD50 is 1690mg/kg in rats, acute percutaneous is LD50>5278mg/kg in rabbits, acute transdermal is LD50>2000mg/kg in rats. It has a stimulating effect on the eyes of rabbits. The accumulative coefficient K value is >5, which belongs to the mild accumulative pesticide.There is no teratogenic, carcinogenic and mutagenic effects on animals within the range of experiments. No abnormality is found in the three generation reproduction test and neurotoxicity test. The non-cation dose for two years of feeding test: 200mg/kg for rats,LC50388mg/L for rainbow trout, LD50>5000mg/kg for quail, LD50>10000mg/kg for wild duck and, LC5060μg for per bee.
Production Methods
Hexazinone is a postemergence contact herbicide effective
against many annual and biennial weeds and, except for
Johnson grass, most perennial weeds. Human contact is
likely at the use stage, and dermal contact and inhalation
are of most concern.
General Description
White crystalline solid. Corrosive eye irritant. Used as an herbicide.
Air & Water Reactions
Water soluble. Rapidly decomposed in solution by strong acids and bases.
Reactivity Profile
A triazine.
Carcinogenicity
No carcinogenicity was detected
among pups of rats fed up to 5000 ppm for 2 years.
Similarly, no increase in tumors was produced by feeding up
to 10,000 ppm hexazinone to mice.
Environmental Fate
Soil/Plant. Biodegrades in soil and natural waters releasing carbon dioxide. The reported half-life in soil is 1 to 6 months (Hartley and Kidd, 1987). Rhodes (1980a) found that the persistence of hexazinone varied from 4 weeks in a Delaware sandy loam to 24 weeks in a Mississippi silt loam.Hexazinone is subject to microbial degradation (Rhodes, 1980a; Feng, 1987). Metabolites identified in soils, alfalfa and/or sugarcane include 3-(4-hydroxycyclohexyl)-6(dimethylamino)-1-methyl-1,3,5-triazine-2,4(1H,3H)-dione, 3-cyclohexyl-6-(methylamino)-1Feng (1987) monitored the persistence and degradation of hexazinone in a silt loam soil 104 days after treatment of the herbicide. After 104 days, 66% of the hexazinone degraded via hydroxylation to form the major metabolite 3-(4-hydroxycyclohexyl)-6(dimeNo traces of hexazinone or its metabolites were detected on treated blueberries (Jenson and Kimball, 1985).Photolytic. Photodegradation products identified in aqueous hexazinone solutions following exposure to UV light (λ = 300–400 nm) were 3-(4-hydroxycyclohexyl)-6-(dimethylamino)-1-methyl-1,3,5-triazine-2,4(1H,3H)-dione, 3-cyclohexyl-6-(methylamino)
Metabolic pathway
In clay and sand soils, hexazinone is metabolized by
hydroxylation at the 4-position of the cyclohexane ring
and mono-N-demethylation to give [3-(4-
hydroxycyclohexyl)-6-(dimethylamino)-1-methyl-1,3,5-
triazine-2,4-(1H,3H )-dione], and [3-cyclohexyl-6-
(methylamino)-1-methyl-1,3,5-triazine-2,4-(1H,3H )-
dione, respectively. N-Demethylated metabolite is
found in a comparatively higher percentage than the
hydroxylated metabolite in both clay and sand soils.
Check Digit Verification of cas no
The CAS Registry Mumber 51235-04-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,1,2,3 and 5 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 51235-04:
(7*5)+(6*1)+(5*2)+(4*3)+(3*5)+(2*0)+(1*4)=82
82 % 10 = 2
So 51235-04-2 is a valid CAS Registry Number.
InChI:InChI=1/C12H20N4O2/c1-14(2)10-13-11(17)16(12(18)15(10)3)9-7-5-4-6-8-9/h9H,4-8H2,1-3H3
51235-04-2Relevant articles and documents
Novel method for synthesizing benzoxazinone (by machine translation)
-
Paragraph 0045, (2019/09/05)
The invention discloses a novel method for synthesizing benzoxazinone, and belongs to the technical field of synthesis. The method is: in the condition that toluene is taken as a solvent, and an acid binding agent is added, guanidine and auxiliary A are reacted to prepare a guanidyl ethyl ester; after water is removed by layering and distillation, cyclohexylamine is added with the substance such as guanidine, and is reacted, under the action of a catalyst, with ethyl guanidine formate to prepare the benzoxazinone. Compared with the existing synthetic method, the method has the advantages of high safety and strong operability, and compared with the existing synthetic method, the method has the advantages of high safety, and strong operability. Without rectification, the utility model has good application value. (by machine translation)
5,6-Dihydro-1,2,4,6-thiatriazin-5-one-1,1-dioxides
-
, (2008/06/13)
5,6-Dihydro-1,2,4,6-thiatriazin-5-one-1,1-dioxides of the formula STR1 where R1 is hydrogen, a metal atom or an unsubstituted or substituted ammonium radical, R2 is a saturated or unsaturated straight-chain aliphatic radical of up to 10 carbon atoms, a cycloaliphatic radical or 3 to 7 carbon atoms, a branched saturated or unsaturated aliphatic radical of 3 to 10 carbon atoms, a halogen-, alkoxy- or alkylmercapto-substituted aliphatic radical of 2 to 10 carbon atoms tetrahydrofuryl substituted methyl, a cycloalkoxy-substituted aliphatic radical of 4 to 10 carbon atoms, unsubstituted or halogen-substituted benzyl or phenyl, halophenyl, or alkylphenyl of a total of up to 10 carbon atoms, R3 is hydrogen, a straight-chain aliphatic radical of up to 10 carbon atoms, a cycloaliphatic radical of 3 to 7 carbon atoms, a branched aliphatic radical of 3 to 10 carbon atoms, haloalkyl, or alkoxyalkyl of 2 to 10 carbon atoms and X is oxygen and may also be sulfur if R2 is unsubstituted or halogen-substituted benzyl, processes for their preparation, and herbicides containing the above compounds.
Process for preparing herbicidal triazines
-
, (2008/06/13)
An improved process for preparing 3-cyclohexyl-1-methyl-6-dimethylamino-s-triazine-2,4(1H,3H)dione by the following reaction sequence: STR1 the improvement comprising using R=ethyl, n-propyl or isopropyl, preferably ethyl, thus permitting significantly higher practical overall yields. Related 3-substituted-1-methyl-6-substituted amino-s-triazine-2,4(1H,3H)diones and 4-thio-2,4(1H,3H)-diones are prepared similarly. These products are useful as herbicides.
