51264-73-4

Basic information

• Product Name: ethyl 2-(4-formylphenoxy)propionate
• Synonyms: ethyl 2-(4-formylphenoxy)propionate;2-(4-Formylphenoxy)propionic acid ethyl ester
• CAS NO: 51264-73-4
• Molecular Formula: C₁₂H₁₄O₄
• Molecular Weight: 222.23716
• EINECS: 257-095-9
• Mol File: 51264-73-4.mol

Chemical Properties

• Boiling Point: 335.9°Cat760mmHg
• Flash Point: 147.5°C
• Appearance: /
• Density: 1.139g/cm³
• Vapor Pressure: 0.000116mmHg at 25°C
• Refractive Index: 1.527
• CAS DataBase Reference: ethyl 2-(4-formylphenoxy)propionate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-(4-formylphenoxy)propionate(51264-73-4)
• EPA Substance Registry System: ethyl 2-(4-formylphenoxy)propionate(51264-73-4)

Safety Data

• Hazardous Substances Data: 51264-73-4(Hazardous Substances Data)

Usage

InChI:InChI=1/C12H14O4/c1-3-15-12(14)9(2)16-11-6-4-10(8-13)5-7-11/h4-9H,3H2,1-2H3

Upstream product

• 123-08-0 4-hydroxy-benzaldehyde 
• 68-12-2 N,N-dimethyl-formamide 
• 535-13-7 2-chloro-propanoic acid, ethyl ester 
• 58742-64-6 ethyl l-2-((methylsulfonyl)oxy)propionate 
• 535-11-5 Ethyl 2-bromopropionate 

Downstream Products

• 70044-37-0 Ethyl-2-<4-(hydroxymethyl)phenoxy>propionat 
• 1361043-99-3 ethyl 2-(4-(bis(2-methyl-1H-indol-3-yl)methyl)phenoxy)propanoate 
• 1361043-98-2 ethyl 2-(4-(bis(1-methyl-1H-indol-3-yl)methyl)phenoxy)propanoate 
• 1361044-01-0 ethyl 2-(4-(bis(1,2-dimethyl-1H-indol-3-yl)methyl)phenoxy)propanoate 
• 1361044-00-9 ethyl 2-(4-(bis(1-ethyl-1H-indol-3-yl)methyl)phenoxy)propanoate 
• 65343-67-1 ethyl 2-(4-hydroxyphenoxy)propanoate 

Relevant articles and documents

Microwave-assisted efficient synthesis of pyrazole-fibrate derivatives as stimulators of glucose uptake in skeletal muscle cells

The design and synthesis of a series of pyrazolo[3,4-d]pyrimidinones containing fibrate side chains have been accomplished by utilizing the concept of molecular hybridization. All the synthesized compounds were evaluated for the glucose uptake stimulatory effect in L6 rat skeletal muscle cells. Four compounds (3f, 3g, 3j and 3q) were found to show significant stimulation of glucose uptake. Further these four compounds have been examined for their Glut4 translocation stimulatory effect in L6-Glut4myc myotubes. Compound 3q was found to exert maximum increase in GLUT4myc translocation.

Indole-based fibrates as potential hypolipidemic and antiobesity agents

Hypolipidemic and antiobesity effects of the newly synthesized indole-based fibrates were evaluated in Triton WR-1339 and high fat diet (HFD)-induced hyperlipidemic rats. Preliminary screening of all the synthesized compounds was done by using an acute model (Triton model), in which compounds 3f and 3l showed significant antidyslipidemic activity. Furthermore, these compounds 3f and 3l were found to induce significant weight loss in the visceral fat mass of HFD-fed hyperlipidemic rats without affecting the normal feeding behavior. Histological examination of the liver of rats supplemented with 3f and 3l revealed a significant decrease in steatosis when compared to the effect of the standard drug fenofibrate. Additional effects such as an increase in lecithin cholesterol acyl-transferase (LCAT) enzyme level and increased receptor mediated catabolism of I131-low density lipoproteins (LDL) confirm and reinforce the efficacy of both of these compounds as a new class of dual-acting hypolipidemic and antiobesity agents.

HYPOPHOSPHOROUS ACID DERIVATIVES HAVING ANTIHYPERALGIC ACTIVITY AND BIOLOGICAL APPLICATIONS THEREOF

The invention relates to hypophosphorous acid derivatives of formula (I) wherein - X is H or OH, - R represents one or several radicals R1-R5, identical or different, two of R1-R5 optionally occupying the same position on the phenyl group, one to four of R1-R5 being H and the others being selected in the group comprising - 0-(CH2)n-COOH; - S-(CH2)n-COOH; -NH-(CH2)n-COOH; - 0-(CH,R') -COOH; -O- (CH2)n-OH; OR', -R' being a C1 -C3 alkyl radical;-OH; --COOH; halogen, particularly -F, - CI, -Br, -I, -CF3; -OCF3; -N02; -CH=CH-COOH; - -(CH2)n-COOH; O - (CH2)n- P03H2; O - (CF2)n- P03H2; O - (CH2)n- S03H; O - (CH2)n- CONHOH; O - (CH2)n-tetrazol; O - (CH2)n-hydroxyisoxazol - n = 1 to 5, preferably 1-3; said hypophosrous acid derivatives being diastereoisomers or enantiomers.

Process for producing 2-(4-hydroxyphenoxy) propionate derivatives

A process for producing a 2-(4-hydroxyphenoxy) propionate derivative represented by the formula: STR1 where Alk is a C1 -C5 alkyl group, which comprises reacting a phenoxy propionate derivative represented by the formula: STR2 where Alk is as defined above, with a peroxide to obtain a formate derivative represented by the formula: STR3 where Alk is as defined above, and hydrolyzing the formate of the formula III.