512785-91-0Relevant academic research and scientific papers
Catalytic reductive carbon-carbon bond-forming reactions of alkynes
Miller, Karen M.,Molinaro, Carmela,Jamison, Timothy F.
, p. 3619 - 3625 (2007/10/03)
Enantioselective nickel/phosphine-catalyzed reductive coupling of alkynes and aldehydes provides rapid access to synthetically useful allylic alcohols with high enantiomeric excess. A related reaction involving epoxides is enantiospecific, transforming al
Catalytic asymmetric reductive coupling of alkynes and aldehydes: Enantioselective synthesis of allylic alcohols and α-hydroxy ketones
Miller, Karen M.,Huang, Wei-Sheng,Jamison, Timothy F.
, p. 3442 - 3443 (2007/10/03)
A highly enantioselective method for catalytic reductive coupling of alkynes and aldehydes is described. Allylic alcohols are afforded with complete E/Z selectivity, generally >95:5 regioselectivity, and in up to 96% ee. In conjunction with ozonolysis, th
