512825-94-4

Basic information

• Product Name: ethyl 5-cyclopropyl-7-(difluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxylate
• Synonyms: ethyl 5-cyclopropyl-7-(difluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxylate;pyrazolo[1,5-a]pyrimidine-3-carboxylic acid, 5-cyclopropyl-7-(difluoromethyl)-, ethyl ester;5-cyclopropyl-7-(difluoromethyl)-3-pyrazolo[1,5-a]pyrimidinecarboxylic acid ethyl ester;5-cyclopropyl-7-(difluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid ethyl ester;AK-968/41923297;MLS000065223;SMR000078823;ZINC00374418
• CAS NO: 512825-94-4
• Molecular Formula: C13H13F2N3O2
• Molecular Weight: 281.2580264
• Mol File: 512825-94-4.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: ethyl 5-cyclopropyl-7-(difluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 5-cyclopropyl-7-(difluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxylate(512825-94-4)
• EPA Substance Registry System: ethyl 5-cyclopropyl-7-(difluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxylate(512825-94-4)

Safety Data

• Hazardous Substances Data: 512825-94-4(Hazardous Substances Data)

Upstream product

• 6994-25-8 3-amino-4-pyrazolecarboxylic acid ethyl ester 

Downstream Products

• 438227-80-6 5-cyclopropyl-7-(difluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid 
• 676248-90-1 N-cyclohexyl-5-cyclopropyl-7-(difluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide 

Relevant articles and documents

Pharmacophore-based virtual screening for identification of negative modulators of GLI1 as potential anticancer agents

Starting from known GLI1 inhibitors, a pharmacophore-based virtual screening approach was applied to databases of commercially available compounds with the aim of identifying new GLI1 modulators. As a result, three different chemical scaffolds emerged that were characterized by a significant ability to reduce the transcriptional activity of the endogenous Hedgehog-GLI pathway and GLI1 protein level in murine NIH3T3 cells. They also showed a micromolar antiproliferative activity in human melanoma (A375) and medulloblastoma (DAOY) cell lines, without cytotoxicity in non-neoplastic mammary epithelial cells.