51296-12-9Relevant academic research and scientific papers
Oxidation products of phenolic thiocolchicines: Ring a quinones and dienones
Guan, Jian,Brossi, Arnold,Zhu, Xiao-Kang,Wang, Hui-Kang,Lee, Kuo-Hsiung
, p. 1585 - 1591 (2007/10/03)
An improved, highly selective demethylation of thiocolchicine (1) to the diphenol 5 is described. Oxidation of 2 to para-quinone 6 and of 4 and 5 to ortho-quinones 8 and 10 is first reported. Also, 2-demethylthiocolchicine (3) was oxidized to the quinone methide 7.
SELECTIVE ETHER-CLEAVAGE OF THIOCOLCHICOSIDE AND THIOCOLCHICINE: CHARACTERIZATION OF 3- AND 2-DIMETHYLTHIOCOLCHICINE AND CATECHOLIC CONGENERS
Sharma, Padam N.,Brossi, Arnold
, p. 1587 - 1590 (2007/10/02)
Selective ether cleavage in the thiocolchicine series took a similar course as observed in the colchicine series.Thiocolchicoside (2) afforded with phosphoric acid, the known 3-demethylthiocolchicine (6), and thiocolchicine (1) gave with conc. sulfuric acid at 70 deg C, a mixture of the 2-demethylthiocolchicine (3) and the catechols 4 and 5.
