87424-26-8Relevant articles and documents
Antitumor agents. Part 236: Synthesis of water-soluble colchicine derivatives
Nakagawa-Goto, Kyoko,Chen, Cyril X.,Hamel, Ernest,Wu, Chin-Chung,Bastow, Kenneth F.,Brossi, Arnold,Lee, Kuo-Hsiung
, p. 235 - 238 (2007/10/03)
Water-soluble colchicine derivatives were synthesized from 2-demethylcolchicine and 2-demethylthiocolchicine and evaluated in vitro against human tumor cell replication and for inhibition of tubulin polymerization. The glycinate esters (4, 5) and their ta
SELECTIVE ETHER-CLEAVAGE OF THIOCOLCHICOSIDE AND THIOCOLCHICINE: CHARACTERIZATION OF 3- AND 2-DIMETHYLTHIOCOLCHICINE AND CATECHOLIC CONGENERS
Sharma, Padam N.,Brossi, Arnold
, p. 1587 - 1590 (2007/10/02)
Selective ether cleavage in the thiocolchicine series took a similar course as observed in the colchicine series.Thiocolchicoside (2) afforded with phosphoric acid, the known 3-demethylthiocolchicine (6), and thiocolchicine (1) gave with conc. sulfuric acid at 70 deg C, a mixture of the 2-demethylthiocolchicine (3) and the catechols 4 and 5.