51299-16-2 Usage
Uses
Used in Pharmaceutical Industry:
4,4'-bis-(3-trifluoromethyl-phenyl)-1,1'-ethane-1,2-diyl-bis-piperazine is used as an impurity in Filbanserin (F336750) for the treatment of hypoactive sexual desire disorder in females. Its presence in the medication is due to its ability to bind with high affinity to serotonin-5HT1A receptors and dopamine receptors, with Ki values ranging from 4-24 nM. This interaction with the receptors plays a role in modulating the desired therapeutic effects of Filbanserin.
Additionally, due to its receptor-binding properties, 4,4'-bis-(3-trifluoromethyl-phenyl)-1,1'-ethane-1,2-diyl-bis-piperazine may have potential applications in other areas of pharmaceutical research and development, particularly in the development of new medications targeting the serotonin and dopamine systems for various therapeutic purposes. However, further research and development would be required to explore these potential applications.
Check Digit Verification of cas no
The CAS Registry Mumber 51299-16-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,1,2,9 and 9 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 51299-16:
(7*5)+(6*1)+(5*2)+(4*9)+(3*9)+(2*1)+(1*6)=122
122 % 10 = 2
So 51299-16-2 is a valid CAS Registry Number.
51299-16-2Relevant academic research and scientific papers
Synthesis of new 1,2,3-benzotriazin-4-one-arylpiperazine derivatives as 5-HT(1A) serotonin receptor ligands
Caliendo, Giuseppe,Fiorino, Ferdinando,Grieco, Paolo,Perissutti, Elisa,Santagada, Vincenzo,Severino, Beatrice,Bruni, Giancarlo,Romeo, Maria Rosaria
, p. 533 - 538 (2007/10/03)
A series of novel 1,2,3-benzotriazin-4-one derivatives was prepared and evaluated as ligands for 5-HT receptors. Radioligand binding assays proved that the majority of the novel compounds behaved as good to excellent ligands at the 5-HT(1A) receptor, some of which were selective with respect 5-HT(2A) and 5-HT(2C) receptors. Six analogues (1a, 2a, 2b, 2c, 2e and 2i) were selected and further evaluated for their binding affinities on D1, D2 dopaminergic and α1-, α2-adrenergic receptors. A o-OCH3 derivative (2e) bound at 5-HT(1A) sites with subnanomolar affinity (IC50=0.059 nM) and shows high selectivity over all considered receptors and may offer a new lead for the development of therapeutically efficacious agents. Copyright (C) 2000 Elsevier Science Ltd.
