Cas 51299-22-0,4,4'-bis-(3-chloro-phenyl)-1,1'-ethane-1,2-diyl-bis-piperazine

51299-22-0

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Basic information

Product Name: 4,4'-bis-(3-chloro-phenyl)-1,1'-ethane-1,2-diyl-bis-piperazine
Synonyms:
CAS NO:51299-22-0
Molecular Formula:
Molecular Weight: 419.397
EINECS: N/A
Product Categories: N/A

Chemical Properties

Melting Point: N/A
Boiling Point: N/A
Flash Point: N/A
Appearance: N/A
Density: N/A
Refractive Index: N/A
Storage Temp.: N/A
Solubility: N/A
CAS DataBase Reference: 4,4'-bis-(3-chloro-phenyl)-1,1'-ethane-1,2-diyl-bis-piperazine(CAS DataBase Reference)
NIST Chemistry Reference: 4,4'-bis-(3-chloro-phenyl)-1,1'-ethane-1,2-diyl-bis-piperazine(51299-22-0)
EPA Substance Registry System: 4,4'-bis-(3-chloro-phenyl)-1,1'-ethane-1,2-diyl-bis-piperazine(51299-22-0)

Safety Data

Hazard Codes: N/A
Statements: N/A
Safety Statements: N/A
WGK Germany:
RTECS:
HazardClass: N/A
PackingGroup: N/A
Hazardous Substances Data: 51299-22-0(Hazardous Substances Data)

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Check Digit Verification of cas no

The CAS Registry Mumber 51299-22-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,1,2,9 and 9 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 51299-22:
(7*5)+(6*1)+(5*2)+(4*9)+(3*9)+(2*2)+(1*2)=120
120 % 10 = 0
So 51299-22-0 is a valid CAS Registry Number.

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51299-22-0Relevant academic research and scientific papers

Synthesis and biological activity of benzotriazole derivatives structurally related to trazodone

Caliendo, G.,Carlo, R. Di,Greco, G.,Meli, R.,Novellino, E.,et al.

, p. 77 - 84 (1995)

This paper outlines the synthesis and the pharmacological screening of a series of novel 1- and 2-ethyl>benzotriazoles and 1-propoxy>benzotriazoles, which are structurally related to trazodone.Antiserotonergic, antiadrenergic and antihistaminic in vitro activity and in vivo analgesic action are described.Some of the investigated compounds show overall pharmacological profiles similar to that of the antidepressant trazodone. benzotriazole / antiserotonergic activity / antiadrenergic activity / antihistaminic activity / analgesic activity

Synthesis of new 1,2,3-benzotriazin-4-one-arylpiperazine derivatives as 5-HT(1A) serotonin receptor ligands

Caliendo, Giuseppe,Fiorino, Ferdinando,Grieco, Paolo,Perissutti, Elisa,Santagada, Vincenzo,Severino, Beatrice,Bruni, Giancarlo,Romeo, Maria Rosaria

, p. 533 - 538 (2007/10/03)

A series of novel 1,2,3-benzotriazin-4-one derivatives was prepared and evaluated as ligands for 5-HT receptors. Radioligand binding assays proved that the majority of the novel compounds behaved as good to excellent ligands at the 5-HT(1A) receptor, some of which were selective with respect 5-HT(2A) and 5-HT(2C) receptors. Six analogues (1a, 2a, 2b, 2c, 2e and 2i) were selected and further evaluated for their binding affinities on D1, D2 dopaminergic and α1-, α2-adrenergic receptors. A o-OCH3 derivative (2e) bound at 5-HT(1A) sites with subnanomolar affinity (IC50=0.059 nM) and shows high selectivity over all considered receptors and may offer a new lead for the development of therapeutically efficacious agents. Copyright (C) 2000 Elsevier Science Ltd.

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