51307-89-2

Upstream product

• 190187-51-0 4,4'-bis(4-trifluoromethyl)benzophenone O-methylsulfonyloxime 
• 402-43-7 p-trifluoromethylphenyl bromide 
• 455-18-5 4-CF₃C₆H₄CN 
• 246872-10-6 4,4'-bis(trifluoromethyl)benzophenone oxime 
• 21221-91-0 4,4'-bis(trifluoromethyl)benzophenone 

Downstream Products

• 21221-91-0 4,4'-bis(trifluoromethyl)benzophenone 
• 1013084-62-2 4-fluoro-5-phenyl-5-(trifluoromethyl)-2,2-bis(4-trifluoromethylphenyl)-2,5-dihydro-1,3-oxazole 

Relevant academic research and scientific papers

DIAMINO ACID DERIVATIVE STARTING MATERIAL, MANUFACTURING METHOD THEREOF, AND DIAMINO ACID DERIVATIVE MANUFACTURING METHOD

Provided is an efficient technology for synthesizing diamino acids (diamino acid derivatives). Disclosed is a manufacturing method for diamino acid derivatives wherein the fluorenyl groups of the diamino acid derivative starting materials represented by General Formula [II] or [IV] are removed.

Synthesis of pyrrole derivatives by palladium-catalyzed cyclization of γ,δ-unsaturated ketone o-pentafluorobenzoyloximes

Various pyrrole derivatives are synthesized from γ,δ-unsaturated ketone O-pentafluorobenzoyloximes by treatment with catalytic amounts of Pd(PPh3)4 and triethylamine via alkylideneaminopalladium(II) intermediates generated by oxidative addition of the oximes to the Pd(0) complex.

Preparation of primary amines by the alkylation of O-sulfonyloximes of benzophenone derivatives with Grignard reagents

Primary amines are prepared by the electrophilic amination of Grignard reagents with benzophenone O-sulfonyloxime derivatives. 4,4'- Bis(trifluoromethyl)benzophenone O-sulfonyloximes react with alkyl Grignard reagents in the presence of a catalytic amount of CuCN in tetrahydrofuran- hexamethylphosphoric triamide to give N-alkylimines, which are readily hydrolyzed to primary amines. 3,3',5,5'-Tetrakis(trifluoromethyl)benzophenone O-p-tolylsulfonyloxime is arylated to the corresponding N-arylimines with aryl Grignard reagents in ether-toluene, and hydrolysis of the resulting imines gives aniline derivatives.

Preparation of primary amines by the copper(I) catalyzed reaction of 4,4'-bis(trifluoromethyl)benzophenone O-methylsulfonyloxime and alkyl Grignard reagents

Primary amines are prepared by the reaction of 4,4'-bis-(trifluoromethyl)benzophenone O-methylsulfonyloxime and alkyl Grignard reagents in the presence of a catalytic amount of CuCN-2LiCl and the successive acid hydrolysis of the resulting N-alkylimine derivatives.