190187-51-0Relevant academic research and scientific papers
Preparation of primary amines by the alkylation of O-sulfonyloximes of benzophenone derivatives with Grignard reagents
Tsutsui, Hironori,Ichikawa, Tomoko,Narasaka, Koichi
, p. 1869 - 1878 (2007/10/03)
Primary amines are prepared by the electrophilic amination of Grignard reagents with benzophenone O-sulfonyloxime derivatives. 4,4'- Bis(trifluoromethyl)benzophenone O-sulfonyloximes react with alkyl Grignard reagents in the presence of a catalytic amount of CuCN in tetrahydrofuran- hexamethylphosphoric triamide to give N-alkylimines, which are readily hydrolyzed to primary amines. 3,3',5,5'-Tetrakis(trifluoromethyl)benzophenone O-p-tolylsulfonyloxime is arylated to the corresponding N-arylimines with aryl Grignard reagents in ether-toluene, and hydrolysis of the resulting imines gives aniline derivatives.
Preparation of primary amines by the copper(I) catalyzed reaction of 4,4'-bis(trifluoromethyl)benzophenone O-methylsulfonyloxime and alkyl Grignard reagents
Tsutsui, Hironori,Hayashi, Yujiro,Narasaka, Koichi
, p. 317 - 318 (2007/10/03)
Primary amines are prepared by the reaction of 4,4'-bis-(trifluoromethyl)benzophenone O-methylsulfonyloxime and alkyl Grignard reagents in the presence of a catalytic amount of CuCN-2LiCl and the successive acid hydrolysis of the resulting N-alkylimine derivatives.
