51314-50-2

Upstream product

• 17425-17-1 N-(2-methylphenyl)-methyl dithiocarbamic acid 
• 95-54-5 1,2-diamino-benzene 
• 614-69-7 2-tolyl isothiocyanate 
• 14223-44-0 1-isoselenocyanato-2-methylbenzene 
• 50717-64-1 N-(2-amino-phenyl)-N'-o-tolyl-thiourea 
• 615-36-1 2-bromoaniline 
• 123375-81-5 N-(2-bromophenyl)guanidine 
• 615-37-2 ortho-methylphenyl iodide 

Relevant academic research and scientific papers

Potassium Periodate Mediated Oxidative Cyclodesulfurization toward Benzofused Nitrogen Heterocycles

A convenient oxidative cyclodesulfurization method toward the synthesis of benzofused nitrogen heterocycles using inexpensive and readily available potassium periodate as an oxidant was developed. Upon treating isothiocyanates with ortho -substituted anilines bearing N, N -, N, O -, and N, S -bis-nucleophiles, followed by an intramolecular cyclization of the in situ generated monothioureas, substituted 2-aminobenzazole series were rapidly accessible in good to excellent yields. The protocol can accommodate various substituents on both substrates while allowing more efficient, greener, and operational simpler process relative to other oxidative coupling reactions. Tetracyclic quinazolinone derivatives were also afforded in high yields in a single preparative step and chromatography-free.

Copper-promoted one-pot approach: Synthesis of benzimidazoles

A facile, one-pot, and proficient method was developed for the production of various 2-arylaminobenzimidazoles. This methodology is based for the first time on a copper catalyst promoted domino C-N cross-coupling reaction for the generation of 2-arylaminobenzimidazoles. Mechanistic investigations revealed that the synthetic pathway involves a copper-based desulphurization/nucleophilic substitution and a subsequent domino intra and intermolecular C-N cross-coupling reactions. Some of the issues typically encountered during the synthesis of 2-arylaminobezimidazoles, including the use of expensive catalytic systems and the low reactivity of bromo precursors, were addressed using this newly developed copper-catalyzed method. The reaction procedure is simple, generally with excellent substrate tolerance, and provides good to high yields of the desired products.

Novel synthesis of 2-aminobenzimidazoles from isoselenocyanates

An efficient one-pot procedure for the synthesis of 2-aminobenzimidazoles from isoselenocyanates and various substituted diamines is described. Precipitation of elemental selenium from the reaction mixture greatly simplifies the purification procedure and also allows it to be re-used for preparation of isoseleno?cyanates. A possible mechanism for the formation of 2-aminobenzimidazoles is proposed. Georg Thieme Verlag Stuttgart - New York.

A one-pot method for the synthesis of 2-aminobenzimidazoles and related heterocycles

A rapid and efficient one-pot method for the synthesis of 2-aminobenzimidazoles and related heterocycles is described. The reaction is mediated by a polymer-supported carbodiimide, which simplifies product isolation. The scope and limitations of this method are described.

Substituted benzimidazoles, processes for their preparation, their use as medicaments, and medicaments comprising them

The invention relates to the use of compounds of formula I for the production of a medicament for the treatment of illnesses which can be influenced by inhibition of the Na+/H+ exchanger, and to a medicament comprising them. in which R1 to R9 have the meanings shown in the claims.