51319-18-7

Usage

Type of compound

Sympathomimetic amine

Common uses

Decongestant, bronchodilator, stimulant, appetite suppressant, precursor in the manufacture of methamphetamine

Chirality

Chiral compound with two enantiomers

Natural sources

Found in various botanical sources such as the Ephedra plant

Mechanism of action

Non-selective agonist of the adrenergic receptors, leading to increased heart rate, vasoconstriction, and increased blood pressure

Legal status

Controlled substance in many countries due to potential for abuse and adverse cardiovascular effects.

Upstream product

• 96-09-3 styrene oxide 
• 107-11-9 1-amino-2-propene 
• 1634-04-4 tert-butyl methyl ether 
• 29858-07-9 magnesium bromide diethyl etherate 

Relevant academic research and scientific papers

Solvent-Directed Epoxide Opening with Primary Amines for the Synthesis of β-Amino Alcohols

An efficient synthesis of β-amino alcohols from a variety of epoxides and primary unbranched amines in the absence of any catalyst in high yields and regioselectivities is reported. A variety of polar mixed solvent systems allow for the selective formation of secondary amino alcohols over tertiary amino alcohols. The reaction scope extends to a wide variety of aromatic and aliphatic substituted epoxides and primary amines bearing complex functionality.

Process for preparing 1,2-diamino compounds

The invention provides a multistep process for preparing 1,2-diamino compounds and pharmaceutically acceptable addition salts thereof from 1,2-epoxides.

Stereospecific preparation of (3S,4R,5R)-3-(1-hydroxyethyl)-4-benzoyloxy-azeridinones from L-(-)-theonine

Azetidinones represented by the formula STR1 are prepared by a multistep process from L-(-)-theonine via an epoxyamide.