51336-09-5

Basic information

• Product Name: N-benzylisoquinoline-1-amine
• Synonyms: N-benzylisoquinoline-1-amine
• CAS NO: 51336-09-5
• Molecular Weight: 234.301
• Mol File: 51336-09-5.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: N-benzylisoquinoline-1-amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-benzylisoquinoline-1-amine(51336-09-5)
• EPA Substance Registry System: N-benzylisoquinoline-1-amine(51336-09-5)

Safety Data

• Hazardous Substances Data: 51336-09-5(Hazardous Substances Data)

Upstream product

• 19493-44-8 1-chloroisoquinoline 
• 100-46-9 benzylamine 
• 1532-71-4 1-bromoisoquinoline 
• 1198-30-7 1-isoquinolinecarbonitrile 
• 4383-24-8 N,O-dibenzylhydroxylamine 
• 555-96-4 Benzylhydrazine 
• 17146-21-3 O-(benzyl)benzaldoxime 
• 100-52-7 benzaldehyde 
• 1721-93-3 1-methylisoquinoline 
• 100-47-0 benzonitrile 
• 872-36-6 vinylene carbonate 
• 15421-92-8 N-benzylbenzamidine 

Relevant articles and documents

Synthesis of aminoisoquinolines via Rh-catalyzed [4 + 2] annulation of benzamidamides with vinylene carbonate

A new strategy is developed for the synthesis of 1-aminoisoquinoline derivatives. This Rh(III)-catalyzed [4 + 2] annulation reaction employs benzamidines as efficient directing groups and the vinylene carbonate as an acetylene surrogate. Additionally, the reaction features broad substrate scopes and good yields, only producing carbonate anion as byproduct.

Metal-free, redox-neutral, site-selective access to heteroarylamine via direct radical?radical cross-coupling powered by visible light photocatalysis

Transition-metal-catalyzed C?N bond-forming reactions have emerged as fundamental and powerful tools to construct arylamines, a common structure found in drug agents, natural products, and fine chemicals. Reported herein is an alternative access to heteroarylamine via radical?radical cross-coupling pathway, powered by visible light catalysis without any aid of external oxidant and reductant. Only by visible light irradiation of a photocatalyst, such as a metal-free photocatalyst, does the cascade single-electron transfer event for amines and heteroaryl nitriles occur, demonstrated by steady-state and transient spectroscopic studies, resulting in an amine radical cation and aryl radical anion in situ for C?N bond formation. The metal-free and redox economic nature, high efficiency, and site-selectivity of C?N cross-coupling of a range of available amines, hydroxylamines, and hydrazines with heteroaryl nitriles make this protocol promising in both academic and industrial settings.

Substituted 4-amino-isoquinoline compounds, pharmaceutical composition and method of use

Isoquinoline compounds, compositions containing them and their use in the inhibition of gastric acid secretion in mammals. A compound of the invention is 1-[(2-Methoxyphenylmethyl)amino]isoquinoline hydrochloride.