51337-55-4

Downstream Products

• 119788-41-9 N-(2,3-Diphenyl-2H-pyrazolo<3,4-e>-1,2,4-triazin-7-yl)benzamide 
• 99285-53-7 C₁₁H₈N₈ 
• 119788-42-0 N-(3-Methyl-2-phenyl-2H-pyrazolo<3,4-e>-1,2,4-triazin-7-yl)acetamide 
• 98056-24-7 2-Amino-5,7-diphenyl-3-phenylazopyrazolo<1,5-a>pyrimidine 
• 36386-83-1 2-phenyl-1,2,3-triazole-4-carbonitrile 
• 97426-58-9 2-[(4-Chloro-phenyl)-hydrazono]-2-(3,5-diamino-4-phenylazo-pyrazol-1-yl)-N-phenyl-acetamide 
• 93585-26-3 3,5-diamino-4-phenylazo-1-<α-phenylhydrazono-α-(acetyl)methyl>pyrazole 
• 97426-62-5 N-(3,5-Diamino-4-phenylazo-pyrazole-1-carbothioyl)-acetamide 
• 93585-19-4 1,3-Diphenyl-7-phenylazo-1H-pyrazolo[5,1-c][1,2,4]triazol-6-ylamine 
• 97443-35-1 3-Methyl-1-phenyl-1,6-dihydro-dipyrazolo[3,4-c;3',4'-e]pyridazin-8-ylamine 
• 97426-59-0 2-Amino-6-chloro-5-methyl-3-phenylazo-6H-pyrazolo[1,5-a]pyrimidin-7-one 

Relevant academic research and scientific papers

COMPOUNDS HAVING PSEUDOMONAS ANTI-BIOFILM PROPERTIES

The present invention relates to c-di-GMP lowering chemical compounds having anti- biofilm properties. In particular, the present invention relates to anti-biofilm compounds or salts or tautomers thereof for use in treatment and/or prevention of bacterial biofilm infection in human subjects caused by biofilm-forming bacteria of the genus Pseudomonas, in particular Pseudomonas spp. including P. aeruginosa. Methods of treating such infections in human subjects are contemplated as well. The present inventions further relates to the use of an anti-biofilm compound or a salt or tautomer thereof for dispersing biofilms in industrial water systems.

Pyrazole compounds

Pharmaceutical compositions and compounds are provided. The compounds of the invention have anti-proliferative activity, and may promote apoptosis in cells lacking normal regulation of cell cycle and death. In one embodiment of the invention, formulations

Pyrazole compounds

Pharmaceutical compositions and compounds are provided. The compounds of the invention have anti-proliferative activity, and may promote apoptosis in cells lacking normal regulation of cell cycle and death. In one embodiment of the invention, formulations

Pyrazole compounds

Pharmaceutical compositions and compounds are provided. The compounds of the invention have anti-proliferative activity, and may promote apoptosis in cells lacking normal regulation of cell cycle and death. In one embodiment of the invention, formulations of the compounds in combination with a physiologically acceptable carrier are provided. The pharmaceutical formulations are useful in the treatment of hyperproliferative disorders, which disorders include tumor growth, lymphoproliferative diseases, angiogenesis. The compounds of the invention are substituted pyrazoles and pyrazolines.