51339-26-5

Usage

Uses

Used in Pharmaceutical Synthesis:
(Phenyl)(3-trifluoromethylphenyl)methyl bromide is utilized as a reagent in the organic synthesis of various biologically active molecules and pharmaceuticals. Its unique structure and functional groups contribute to the development of new drugs with improved efficacy and reduced side effects.
Used in Agrochemical Production:
(phenyl)(3-trifluoromethylphenyl)methyl bromide is also employed in the production of agrochemicals, where it serves as an intermediate for synthesizing compounds with pesticidal, herbicidal, or fungicidal properties. Its use in this industry helps to create more effective and targeted agrochemicals for agricultural applications.
Used in Fine Chemicals Industry:
(Phenyl)(3-trifluoromethylphenyl)methyl bromide is used as an intermediate in the synthesis of diverse organic compounds for the fine chemicals industry. Its bromide functional group makes it a versatile building block for creating specialty chemicals with specific applications in various markets, such as fragrances, dyes, and advanced materials.

Upstream product

• 728-80-3 3-(trifluoromethyl)benzhydrol 
• 728-81-4 3-(trifluoromethyl)benzophenone 
• 402-26-6 3-(trifluoromethyl)phenylmagnesium bromide 
• 100-52-7 benzaldehyde 

Downstream Products

• 176713-86-3 [Phenyl-(3-trifluoromethyl-phenyl)-methyl]-phosphonic acid diethyl ester 
• 205389-79-3 [(2-(Phenyl)(3-trifluoromethylphenyl)methylsulfonyl-4,5-dihydronaphtho[1,2-d]thiazol-6-yl)oxy]acetic Acid 
• 728-80-3 3-(trifluoromethyl)benzhydrol 

Relevant academic research and scientific papers

Tricyclic compounds, their production and use

A compound of the formula: wherein R1 is H or a substituent; m is 1-3; Ar is an aromatic group which may be substituted; X is a bond or a divalent straight-chain group having 1-6 atoms which may be substituted; Y is —S—, —O—, or —N(R2— (R2 is H or a substituent group), Z is —N= or —C(R3)= (R3 is H or a hydrocarbon group), ring A is a benzene ring; ring B is a 5- to 7-membered ring which may be substituted, or a salt thereof is useful for eliciting a prostaglandin I2 receptor agonistic effect.

Benzylphosphonic acid inhibitors of human prostatic acid phosphatase

A series of α-substituted benzylphosphonic acids is described as inhibitors of human prostatic acid phosphatase, an enzyme has been used as a model to study aryl phosphatases. The most potent inhibitors in this series are 2-trifluoromethylbenzhydrylphosphonic acid (9 μM), and α-(2-phenylethyl)benzylphosphonic acid (14 μM). The structure-activity studies suggest that bulk tolerance beyond the phosphate binding area limits the steric or hydrophobic contribution to inhibitor potency achieved through α-carbon substitution.

SOLVOLYSES OF MONOSUBSTITUTED BENZHYDRYL BROMIDES. NUCLEOPHILIC SOLVENT INTERVENTION AND DEPENDENCE OF SOLVATATION ON THE EXTENT OF CHARGE DELOCALIZATION IN CATIONIC TRANSITION STATES

Solvolyses of monosubstituted benzhydryl bromides gave excellent linear correlations of logk with ?(1+) constants, and not with Y(BnBr) or Y(Br).Correlation analyses against corresponding logk of α-tert-butyl-(2-naphthyl)methyl bromide provided evidence for the importance of different extent of solvation in delocalized transition state and for nucleophilic solvent intervention in the solvolysis of benzhydryl systems.