51339-31-2Relevant articles and documents
Preparation and application of organic thermally induced delayed fluorescence material containing 9,9-dimethyl acridine unit
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, (2017/08/31)
The invention belongs to the field of organic luminescent materials, and provides preparation and application of an organic thermally induced delayed fluorescence material containing a 9,9-dimethyl acridine unit. Isophthalonitrile with high eletrophilicity is taken as the electron acceptor, a cyano group with a strong electron-withdrawing performance is introduced, 9,9-dimethyl acridine is taken as the electron donor, and a meta-position connection mode is adopted to obtain the organic micromolecular thermally induced delayed fluorescence material with an excellent luminescence property, and the conventional para-position connection mode is broken through. The organic thermally induced delayed fluorescence material, which contains a 9,9-dimethyl acridine unit and adopts a meta-position connection mode, can be applied to vapor deposition of devices. Meanwhile, the organic thermally induced delayed fluorescence material has the advantages of high yield, high thermal stability, and easy film forming, can be massively produced and used in a large scale, and can be applied to electroluminescent devices to obtain a high efficient electroluminescent performance.
Design and synthesis of 8-hydroxy-[1,6]naphthyridines as novel inhibitors of HIV-1 integrase in vitro and in infected cells
Zhuang, Linghang,Wai, John S.,Embrey, Mark W.,Fisher, Thorsten E.,Egbertson, Melissa S.,Payne, Linda S.,Guare Jr., James P.,Vacca, Joseph P.,Hazuda, Daria J.,Felock, Peter J.,Wolfe, Abigail L.,Stillmock, Kara A.,Witmer, Marc V.,Moyer, Gregory,Schleif, William A.,Gabryelski, Lori J.,Leonard, Yvonne M.,Lynch Jr., Joseph J.,Michelson, Stuart R.,Young, Steven D.
, p. 453 - 456 (2007/10/03)
Naphthyridine 7 inhibits the strand transfer of the integration process catalyzed by integrase with an IC50 of 10 nM and inhibits 95% of the spread of HIV-1 infection in cell culture at 0.39 μM. It does not exhibit cytotoxicity in cell culture
HIV integrase inhibitors
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, (2008/06/13)
Certain six-membered aromatic and heteroaromatic-dioxobutyric acid derivatives are described as inhibitors of HIV integrase and inhibitors of HIV replication. These compounds are useful in the prevention or treatment of infection by HIV and the treatment