51351-87-2

Upstream product

• 1950-78-3 p-toluenesulfonyl iodide 
• 29559-26-0 (p-methoxyphenyl)nitromethane 
• 1950-69-2 toluene-p-sulfonyl bromide 
• 105-13-5 4-Methoxybenzyl alcohol 
• 123-11-5 4-methoxy-benzaldehyde 
• 1576-35-8 toluene-4-sulfonic acid hydrazide 

Downstream Products

• 51351-92-9 (4-Methoxy-phenyl)-(toluene-4-sulfonyl)-methanone oxime 

Relevant academic research and scientific papers

Synthesizing method of drug intermediate nitro-substituted sulfonyl compound

The invention relates to a synthesizing method of a nitro-substituted sulfonyl compound which can be used as a drug intermediate and is shown in the formula (III).The method comprises the steps that in an organic solvent, in the presence of a catalyst, a nitro source compound, alkali and an oxidation promotor, a compound of the formula (I) and the compound of the formula (2) react at the temperature ranging from 70 DEG C to 90 DEG C, the reaction time is 4 h-7 h, after the reaction is finished, aftertreatment is conducted, and therefore a compound of the formula (III) is obtained.Please see the formula in the description.R1 and R2 each represents H or C1-C6 alkyl groups or C1-C6 alkoxy groups or a halogen, and X represents a halogen.According to the synthesizing method, by means of combined selection and synergy of a proper reaction substrate, the catalyst, the nitro source compound, alkali, the oxidation promotor and the organic solvent, a target product can be obtained in high yield, and a good application prospect and production potential are achieved in industry.

Iron(III)-Mediated Radical Nitration of Bisarylsulfonyl Hydrazones: Synthesis of Bisarylnitromethyl Sulfones

Iron(III)-mediated radical nitration of bisarylsulfonyl hydrazones is described. In this protocol, the nontoxic and inexpensive Fe(NO3)3·9H2O plays a dual role as catalyst as well as nitro source. The mild conditions, broa