51385-18-3Relevant academic research and scientific papers
Design and synthesis of novel senkyunolide analogues as neuroprotective agents
Fang, Yuanying,Wang, Rikang,Wang, Qi,Sun, Yongbing,Xie, Saisai,Yang, Zunhua,Li, Min,Jin, Yi,Yang, Shilin
, p. 668 - 672 (2018/01/27)
A class of senkyunolide analogues bearing benzofuranone fragment were designed, synthesized and evaluated for their neuroprotective effect in models of oxygen glucose deprivation (OGD) and oxidative stress. All tested compounds showed neuroprotection profile based on the cell viability assay. In particular, derivatives 1f–1i possessing furoxan-based nitric oxide releasing functionality exhibited significant biological activities in OGD models. More importantly, compound 1g containing short linker with furoxan displayed the most potent neuroprotection at the concentration of 100 μM (cell survival up to 145.2%). Besides, 1g also showed the middle level neuroprotective effect in model of oxidative stress.
Isoaurones: synthesis and stereochemical assignments of geometrical isomers
Venkateswarlu, Somepalli,Panchagnula, Gopala K.,Guraiah, Mothukuri Bala,Subbaraju, Gottumukkala V.
, p. 9855 - 9860 (2007/10/03)
A series of isoaurones have been synthesized for the first time from substituted acetophenones via benzo-2(3H)-furanone in three steps. Geometrical isomers of the isoaurones were separated. The differences in the proton and carbon NMR spectra of the E- and Z-isoaurones afford a useful method for distinguishing between the two isomers. Marginalin, a metabolite of Dytiscus marginalis has been synthesized and the spectral data of the synthetic E-isomer were in good agreement with those of the natural product. The antioxidant activity of isoaurones was determined by superoxide free radical (NBT) method and isoaurones 12 and 13 displayed excellent antioxidant activity.
Synthesis of homogentisic acid by carbonylation
Prasad, Chalasani S N,Adapa, Srinivas R
, p. 626 - 627 (2007/10/02)
The synthesis of homogentisic acid by carbonylation of 2,5-dihydroxybenzyl chloride derivative followed by hydrolysis is discussed.
