51385-57-0

Upstream product

• 752993-28-5 (2S,3R,4S,5R,6R)-2-Dihydroxymethyl-6-methoxy-tetrahydro-pyran-3,4,5-triol 
• 57558-34-6 (4S,5R,6R)-4,5-Dihydroxy-6-methoxy-5,6-dihydro-4H-pyran-2-carbaldehyde 
• 128503-23-1 (+/-)-methyl 5-O-benzyl-6-O-t-butyldimethylsilyl-4-deoxy-2,3-O-isopropylidene-DL-lyxo-hexonate 
• 147048-91-7 (+/-)-methyl 5-O-benzyl-4-deoxy-2,3-O-isopropylidene-DL-lyxo-hexonate 
• 128503-22-0 (+/-)-methyl 5-O-benzyl-4-deoxy-lyxo-DL-hexonate 
• 128503-24-2 (+/-)-5-O-benzyl-6-O-(t-butyl)dimethylsilyl-4-deoxy-2,3-O-isopropylidene-DL-lyxo-hexose 
• 1824-94-8 methyl beta-D-galactopyranoside 
• 103946-96-9 methyl β-D-galactopyranoside 3,4-thionocarbonate 
• 124314-26-7 methyl 2,3,6-tri-O-benzoyl-4-O-(p-bromophenylsulfonyl)-β-D-galactopyranoside 
• 124314-27-8 methyl 2,3,6-tri-O-benzoyl-4-O-(trifluoromethylsulfonyl)-β-D-galactopyranoside 
• 124314-28-9 methyl 2,3,6-tri-O-benzoyl-4-O-(imidazol-1-ylthiocarbonyl)-β-D-galactopyranoside 
• 51996-25-9 methyl 2,3,6-tri-O-benzoyl-4-deoxy-4-iodo-β-D-glucopyranoside 
• 34820-01-4 methyl 2,3,6-tri-O-benzoyl-β-D-galactopyranoside 
• 103931-41-5 methyl 3,4-O-thiocarbonyl-β-D-galactopyranoside di-O-acetate 

Downstream Products

• 24707-41-3 4-deoxy-D-galactose 
• 131291-12-8 methyl 2,3-di-O-benzoyl-4-deoxy-6-O-trityl-β-D-xylo-hexopyranoside 
• 131291-11-7 methyl 2,3-di-O-benzoyl-4-deoxy-β-D-xylo-hexopyranoside 
• 131291-18-4 methyl O-(2,3,4,6-tetra-O-benzoyl-β-D-galactopyranosyl)-(1->6)-2,3-di-O-benzoyl-4-deoxy-β-D-xylo-hexopyranoside 
• 23397-23-1 4-deoxy-β-D-xylo-hexopyranose 

Relevant academic research and scientific papers

Chemical Mapping Exposes the Importance of Active Site Interactions in Governing the Temperature Dependence of Enzyme Turnover

Uncovering the role of global protein dynamics in enzyme turnover is needed to fully understand enzyme catalysis. Recently, we have demonstrated that the heat capacity of catalysis, ΔCP?, can reveal links between the protein free energy landscape, global protein dynamics, and enzyme turnover, suggesting that subtle changes in molecular interactions at the active site can affect long-range protein dynamics and link to enzyme temperature activity. Here, we use a model promiscuous enzyme (glucose dehydrogenase from Sulfolobus solfataricus) to chemically map how individual substrate interactions affect the temperature dependence of enzyme activity and the network of motions throughout the protein. Utilizing a combination of kinetics, red edge excitation shift (REES) spectroscopy, and computational simulation, we explore the complex relationship between enzyme–substrate interactions and the global dynamics of the protein. We find that changes in ΔCP? and protein dynamics can be mapped to specific substrate–enzyme interactions. Our study reveals how subtle changes in substrate binding affect global changes in motion and flexibility extending throughout the protein.

Synthesis of Deoxyglycosides by Desulfurization under UV Light

This study was performed to develop a highly efficient method whereby desulfurization could be completed in 0.5 h under ultraviolet light, at room temperature, and in the presence of trialkylphosphine. Using this method, deoxyglycosides could be produced from sulfur-containing glycosides in almost quantitative yields. The much higher reactivity of desulfurization with triethylphosphine versus that with triethylphosphite is also discussed.

TOTAL ASYMMETRIC SYNTHESES OF 3- AND 4-DEOXY-HEXOSES AND DERIVATIVES.

(1S,4S)-7-Oxabicyclohept-5-en-2-one ((-)-5, a "naked sugar") has been converted to (-)-(1R,4S,6S)-6-endo-benzyloxy-2-bromo-7-oxabicyclohept-2-ene ((-)-12) in a highly stereoselective fashion.Double hydroxylation of the C=C double bond of (-)

Synthesis of specifically deoxygenated ligands related to (1->6)-β-D-galacto-oligosaccharides, and studies on their binding to monoclonal antigalactan antibodies

Synthetic deoxygenated derivatives of methyl β-glycosides of (1->6)-β-D-galacto-oligosaccharides were prepared, and their binding to antigalactan monoclonal antibodies X24 and J539 (Fab') was studied.The results suggest the involvement of an additional, critical hydrogen bond in the highest affinity subsite (A), which now appears to require two hydrogen bonds from the 2- and 3-hydroxyls of the galactosyl residue to the protein, and one from the protein to O-4 of that residue.The data obtained with a series of oligosaccharides deoxygenated at position 31, 32,33, 41, 42, or 43 support the binding patterns and subsite-arrangement inferred previously from studies with large numbers of deoxyfluoro-substituted ligands and this family of antibodies.

SYNTHESIS OF SOME DEOXY, UNSATURATED, AND DIDEOXY SUGARS VIA REGIOSELECTIVE THIOACYLATION OF GLYCOPYRANOSIDES BY THE DIBUTYLTIN OXIDE METHOD

Treatment of non-protected glycopyranosides (Me α-D-Glc, Me β-D-Glc, Me α-D-Xyl, and Me β-D-Xyl) with dibutyltin oxide followed by thioacylation with phenoxythiocarbonyl chloride gave the mono-thionocarbonates regioselectively in high yields.Acetylation o