51407-84-2Relevant academic research and scientific papers
Mannich Reaction with 5,5-Dimethyl-3-phenylamino-2-cyclohexen-1-one
Hamama, W. S.,Hammouda, M.,Afsah, E. M.
, p. 483 - 486 (2007/10/02)
Mannich reaction of the title compound 1 with morpholine, piperidine or piperazine gave the keto-bases 2-4, respectively.Whereas, such reaction with primary amines afforded the quinazolinones 5 and 6.Compound 1 reacts with isonicotinic acid hydrazide and formalin to give 7.Schmidt reaction of 4 and 5a gave 8 and 9, respectively.Reduction of the latter afforded the 9H-pyrimidoazepine ring system 10.The reaction of 1 with formalin was investigated. - Keywords: Mannich Bases of Enaminones, Octahydro-9H-pyrimido-azepines, Tetrahydro-4H-benzoxazin-5(6H)-one, Nitrogen Heterocycles
3-Anilino-5,5-disubstituted-2-aminomethyl-2-cyclohexen-1-ones and the salts thereof
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, (2008/06/13)
Novel cyclohexenone derivatives, which are shown by the general formula SPC1 Wherein each of R1 and R2 represents a hydrogen atom, lower alkyl or phenyl group; one of R3 and R4 represents a hydrogen atom or lower alkyl group, and the other represents an unsubstituted or substituted phenyl, lower alkyl or aralkyl group, or R3 and R4, taken together with the adjacent nitrogen atom, form a 5 to 6-membered heterocyclic ring; one of R5 and R6 represents a hydrogen atom or lower alkyl group, and the other represents a lower alkyl, phenyl or aralkyl group, or R5 and R6, taken together with the adjacent nitrogen atom, form an unsubstituted or substituted 5 to 6-membered heterocyclic ring, and their pharmaceutically acceptable salts, useful medicines such as analgesics.
