51410-45-8Relevant articles and documents
Carbonylative C?C Bond Activation of Electron-Poor Cyclopropanes: Rhodium-Catalyzed (3+1+2) Cycloadditions of Cyclopropylamides
Dalling, Andrew G.,Yamauchi, Takayuki,McCreanor, Niall G.,Cox, Lydia,Bower, John F.
supporting information, p. 221 - 225 (2018/12/11)
Rh-catalyzed carbonylative C?C bond activation of cyclopropylamides generates configurationally stable rhodacyclopentanones that engage tethered alkenes in (3+1+2) cycloadditions. These studies provide the first examples of multicomponent cycloadditions t
Achieving regio- and stereo-control in the fluorination of aziridines under acidic conditions
Okoromoba, Otome E.,Li, Zhou,Robertson, Nicole,Mashuta, Mark S.,Couto, Uenifer R.,Tormena, Cláudio F.,Xu, Bo,Hammond, Gerald B.
supporting information, p. 13353 - 13356 (2016/11/18)
We developed an efficient fluorination protocol that converts easily accessible aziridines into β-fluoroamines, which are important motifs in biologically active molecules. In contrast with traditional fluorination approaches, DMPU-HF has shown both highe
Regioselectivity and diasteroselectivity in Pt(II)-mediated "green" catalytic epoxidation of terminal alkenes with hydrogen peroxide: Mechanistic insight into a peculiar substrate selectivity
Colladon, Marco,Scarso, Alessandro,Sgarbossa, Paolo,Michelin, Rino A.,Strukul, Giorgio
, p. 7680 - 7689 (2008/02/05)
Recently developed electron-poor Pt(II) catalyst 1 with the "green" oxidant 35% hydrogen peroxide displays high activity and complete substrate selectivity in the epoxidation of terminal alkenes because of stringent steric and electronic requirements. In the presence of isolated dienes bearing terminal and internal double bonds, epoxidation is completely regioselective toward the production of terminal epoxides. Insight into the mechanism is gained by means of a reaction progress kinetic analysis approach that underlines the peculiar role of 1 in activating both the alkene and H 2O2 in the rate-determining step providing a rare example of nucleophilic oxidation of alkenes by H2O2.