6728-82-1

Basic information

• Product Name: 1-chloro-3-(4-methoxyphenyl)propan-2-ol
• Synonyms: 1-chloro-3-(4-methoxyphenyl)propan-2-ol
• CAS NO: 6728-82-1
• Molecular Weight: 200.665
• Mol File: 6728-82-1.mol

Chemical Properties

• CAS DataBase Reference: 1-chloro-3-(4-methoxyphenyl)propan-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-chloro-3-(4-methoxyphenyl)propan-2-ol(6728-82-1)
• EPA Substance Registry System: 1-chloro-3-(4-methoxyphenyl)propan-2-ol(6728-82-1)

Safety Data

• Hazardous Substances Data: 6728-82-1(Hazardous Substances Data)

Upstream product

• 13139-86-1 4-methoxyphenyl magnesium bromide 
• 106-89-8 epichlorohydrin 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 140-67-0 Estragole 
• 51410-45-8 estragole oxide 

Downstream Products

• 51410-45-8 estragole oxide 
• 6728-83-2 4-(p-Methoxy-phenyl)-3-hydroxy-buttersaeureethylester 
• 6758-06-1 4-(p-Methoxy-phenyl)-3-hydroxy-buttersaeure 
• 6828-50-8 4-(p-Methoxy-phenyl)-3-hydroxy-buttersaeurenitril 

Relevant articles and documents

Taming chlorine azide: Access to 1,2-azidochlorides from alkenes

The in situ preparation and trapping of chlorine azide provided a versatile one-pot method for the azidochlorination of alkenes. Gaseous ClN3 generated from sodium azide, hypochlorite, and acetic acid can be explosive if isolation is attempted. Instead, we generated the reagent in biphasic media in the presence of olefinic compounds dissolved in the organic layer or evenly emulsified throughout the solution in the absence of organic solvent. Under these conditions, ClN3 is created slowly and trapped immediately at the aqueous-organic interface. The resulting safe and reliable procedure provided 1,2-azidochloride derivatives of a variety of substrates, with evidence for both polar and radical mechanisms. Minor impurities characterized in the product mixtures indicated the presence of alternative reaction pathways deriving primarily from radical intermediates.

MODULATORS OF GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-kB ACTIVITY AND USE THEREOF

Novel non-steroidal compounds are provided which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity, including inflammatory and immune diseases, having the structure of formula (I): an en

Substituted heteroaryl amide modulators of glucocorticoid receptor, AP-1, and/or NF-kB activity and use thereof

The present invention relates to new class of non-steroidal compounds which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity including obesity, diabetes, inflammatory- and immune-associ

Tricyclic modulators of the glucocorticoid receptor, AP-1, and/or NF-kB activity and use thereof

Novel non-steroidal compounds are provided which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity including obesity, diabetes, inflammatory and immune diseases, and have the structure of formula (I) or stereoisomers or prodrugs or pharmaceutically acceptable salts thereof, wherein B, J, K, Z, R, Ra, Rb, Rc, Rd, Rq, Rw, m and n are defined herein. Also provided are pharmaceutical compositions and methods of treating obesity, diabetes and inflammatory or immune associated diseases comprising said compounds.

Conversion of epoxides to β-chlorohydrins with thionyl chloride and β-cyclodextrin in water

Several epoxides are efficiently converted to the corresponding β-chlorohydrins in impressive yields with thionyl chloride in the presence of β-cyclodextrin using water as solvent at room temperature. Copyright Taylor & Francis, Inc.

Facile and regioselective conversion of epoxides into β-chlorohydrins using ZrCl4

Epoxides were efficiently converted into the corresponding β-chlorohydrins in good yields by treatment with ZrCl4 in acetonitrile.