51417-15-3

Usage

Molecular Structure

2(1H)-Pyridinone, 3-(chloromethyl)-1-methylis a pyridinone derivative with a chloromethyl group attached to position 3 and a methyl group attached to position 1.

Reactivity

This chemical is highly reactive and can undergo various chemical reactions to produce a range of functionalized pyridinone derivatives.

Uses

It is used as an intermediate in the synthesis of pharmaceutical compounds, agrochemicals, and dyes.

Versatility

2(1H)-Pyridinone, 3-(chloromethyl)-1-methylis a versatile building block in the development of new drugs and other valuable chemical compounds.

Hazardous Nature

This chemical is considered potentially hazardous, and should be handled with care by trained professionals.

Upstream product

• 36721-61-6 3-(hydroxymethyl)-1-methylpyridin-2(1H)-one 
• 609-71-2 2-hydroxy-3-carboxypyridine 
• 15506-18-0 1-methyl-2-oxo-1,2-dihydropyridine-3-carboxylic acid 
• 67367-27-5 methyl 1-methyl-2-oxo-1,2-dihydropyridine-3-carboxylate 
• 42463-41-2 3-(hydroxymethyl)pyridine-2(1H)-one 
• 79138-28-6 1-methyl-2-oxo-1,2-dihydropyridine-3-carbaldehyde 
• 36404-89-4 2-oxo-1,2-dihydro-pyridine-3-carbaldehyde 
• 183274-22-8 trimethylsilyl 2-(trimethylsilyloxy)nicotinate 

Downstream Products

• 672939-82-1 1-methyl-3-(4-octyloxy-phenoxymethyl)-1H-pyridin-2-one 
• 672939-83-2 3-(4-dodecyloxy-phenoxymethyl)-1-methyl-1H-pyridin-2-one 
• 672939-80-9 1-methyl-3-phenoxymethyl-1H-pyridin-2-one 
• 672939-88-7 (1R,2R,5S,6S)-3,7-Dimethyl-1,5-bis-phenoxymethyl-3,7-diaza-tricyclo[4.2.2.2^2,5]dodeca-9,11-diene-4,8-dione 
• 672939-89-8 (1R,2R,5S,6S)-3,7-Dimethyl-1,5-bis-(4-octyloxy-phenoxymethyl)-3,7-diaza-tricyclo[4.2.2.2^2,5]dodeca-9,11-diene-4,8-dione 
• 672939-90-1 (1R,2R,5S,6S)-1,5-Bis-(4-dodecyloxy-phenoxymethyl)-3,7-dimethyl-3,7-diaza-tricyclo[4.2.2.2^2,5]dodeca-9,11-diene-4,8-dione 

Relevant academic research and scientific papers

MTA-Cooperative PRMT5 Inhibitors

The present invention relates to compounds that inhibit Protein Arginine N-Methyl Transferase 5 (PRMT5) activity. In particular, the present invention relates to compounds, pharmaceutical compositions and methods of use, such as methods of treating cancer using the compounds and pharmaceutical compositions of the present invention.

HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF SUMO ACTIVATING ENZYME

Disclosed are compounds of formula (I): or a pharmaceutically acceptable salt thereof; wherein Y, Ra, Ra', Rc, Rf, X2, Rd, Rd', Re, Re', m, and G have the values described herein and stereochemical configurations depicted at asterisked positions indicate absolute stereochemistry, useful as inhibitors of Sumo Activating Enzyme (SAE). Further provided are pharmaceutical compositions comprising a compound of the disclosure and methods of using the compositions in the treatment of proliferative, inflammatory, cardiovascular and neurodegenerative diseases or disorders.

Photoreactivity of 2-pyridones with furan, benzene, and naphthalene. Inter- and intramolecular photocycloadditions

Pyridones, well-known for their ability to photodimerize, have been found to undergo [4 + 4] photocycloaddition with furan and naphthalene but not with benzene. In some cases these reactions can be highly regio- and stereospecific. Intramolecular reaction with furan produces both cis and trans [4 + 4] products. The cycloaddition with naphthalene can occur both inter- and intramolecularly. The intermolecular reaction yields primarily the cis isomer, whereas the trans isomer is the major product from the intramolecular reaction. A mixture of 4-methoxy-2-pyridone and 2- methoxynaphthalene that could form up to eight regio- and stereoisomers forms largely one [4 + 4] product.

Tether-enforced reversal of regioselectivity: Head-to-head [4 + 4] photocycloaddition of 2-pyridones

Symmetric 3,3′-attachment of a three-atom chain between two pyridones overrides the head-to-tail regioselectivity found in intermolecular photodimerization reactions and gives a nearly quantitative yield of the head-to-head [4 + 4] cycloadduct containing contiguous quaternary centres.