51420-46-3

Usage

Uses

Used in Pharmaceutical Industry:
5-(4-morpholinyl)-1H-1,2,4-triazol-3-amine(SALTDATA: FREE) is used as a potential drug candidate for its ability to interact with biological targets and may have therapeutic properties. It is of interest to researchers and pharmaceutical companies for the development of new drugs.
Used in Medicinal Chemistry Research:
5-(4-morpholinyl)-1H-1,2,4-triazol-3-amine(SALTDATA: FREE) is used as a valuable compound for further exploration and study in the field of medicinal chemistry due to its chemical properties and potential biological effects.

Upstream product

• 32885-06-6 S-methyl-N''-cyano-N'-(1-cycloethoxyethyl)carbamimidothioate 
• 103-72-0 phenyl isothiocyanate 
• 135857-19-1 5-Amino-3-morpholin-4-yl-[1,2,4]triazole-1-carbothioic acid N-methyl-hydrazide 

Downstream Products

• 116986-58-4 5-Amino-3-morpholin-4-yl-[1,2,4]triazole-1-carbothioic acid (3-hydroxy-phenyl)-amide 
• 116986-60-8 5-Amino-3-morpholin-4-yl-[1,2,4]triazole-1-carbothioic acid (1-phenyl-ethyl)-amide 
• 117057-03-1 5-Amino-3-morpholin-4-yl-[1,2,4]triazole-1-carbothioic acid (2,4,6-trimethyl-phenyl)-amide 
• 115549-86-5 8-benzyl-2-morpholino-6,7,8,9-tetrahydropyrido<3,4-d>-1,2,4-triazolo<1,5-a>pyrimidin-5(10H)-one 
• 121079-74-1 7,8-dihydro-2-morpholino-7-phenyl-6H-pyrrolo<3,4-d>-1,2,4-triazolo<1,5-a>pyrimidin-5(9H)-one 
• 121079-75-2 butyl 1-phenyl-4-(3-morpholino-1H-1,2,4-triazol-5-yl)imino-3-pyrrolidinecarboxylate 
• 116986-59-5 5-Amino-3-morpholin-4-yl-[1,2,4]triazole-1-carbothioic acid benzylamide 
• 110984-55-9 (5-Amino-3-morpholin-4-yl-[1,2,4]triazol-1-yl)-(3,4,5-trimethoxy-phenyl)-methanone 
• 113362-42-8 5-benzalimino-3-morpholino-1H-1,2,4-triazole 
• 110984-51-5 (5-Amino-3-morpholin-4-yl-[1,2,4]triazol-1-yl)-phenyl-methanone 
• 110984-52-6 (5-Amino-3-morpholin-4-yl-[1,2,4]triazol-1-yl)-(4-chloro-phenyl)-methanone 
• 131049-43-9 2,4-dinitrophenyl (5-amino-3-morpholino-1,2,4-triazol-1-yl)dithiocarbonate 
• 110984-54-8 (5-Amino-3-morpholin-4-yl-[1,2,4]triazol-1-yl)-(3,4-dimethoxy-phenyl)-methanone 
• 113362-43-9 5-benzylamino-3-morpholino-1H-1,2,4-triazole 

Relevant academic research and scientific papers

On Triazoles. XXIX. The Reaction of Triazolyl Thiohydrazides with Isocyanates and Isothiocyanates

Different N-methylsubstituted, N'-methylsubstituted and N,N'-unsubstituted triazol-1-ylcarbothiohydrazides were reacted with isocyanates and isothiocyanates to yield the corresponding carbamoyl and thiocarbamoyl derivatives 4.The thiocarbamoyl derivatives could be cyclised by heating in dimethylformamide or 10percent sodium hydroxide solution, reacting them with dicyclohexylcarbodiimide or thier alkylation to the corresponding 1,3,4-thiadiazoles 12 and 16, and derivatives 5 formed by splitting the triazole moiety.Cleaved derivatives 9 and 11 were also formed in the reaction of thiocarbamoyl derivatives 4 with carbon disulfide in the absence or presence of methyl iodide, respectively.Spectroscopic evidence is given for the structure of products obtained.

On Triazoles. V . Synthesis of 1- and 2-R1-3-R2,R3-Amino-5-amino-1,2,4-triazoles

The correct isomeric and tautomeric structure of different 1- and 2-R1-3-R2,R3-amino-5-amino-1,2,4-triazole derivatives prepared from the corresponding N-cyano-N'-R2,R3-S-methyl-isothioureas and the corresponding hydrazines was proved with the help of their ir, uv, 1H-nmr and 13C-nmr spectra as well as the uv spectra of the Schiff bases of an isomeric pair.